Kuraszkiewicz Bożenna, Chen Jia-Jin Jason, Goszczyńska Hanna, Wang Yu-Lin, Piotrkiewicz Maria
Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
Institute of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
PLoS One. 2018 Jan 16;13(1):e0189845. doi: 10.1371/journal.pone.0189845. eCollection 2018.
This paper extends the observations presented in the previously published work on the afterhyperpolarization (AHP) duration changes in motoneurones (MNs) on the paretic (more affected) side of 11 post-stroke patients by the same analysis on the non-paretic (less-affected) side. The estimated AHP duration for patients' MNs supplying more-affected muscles was significantly longer than control values and the elongation decreased with patient age and disorder duration. For MNs supplying less-affected muscles, dependency of AHP duration on age was closer to the control data, but the scatter was substantially bigger. However, the AHP duration estimate of less-affected MNs tended to be longer than that of controls in the short time elapsed since the stroke, and shorter than controls in the long time. Our results thus suggest that the spinal MNs on both sides respond to the cerebral stroke rapidly with prolongation of AHP duration, which tends to normalize with time, in line with functional recovery. This suggestion is in concert with the published research on post-stroke changes in brain hemispheres. To our knowledge, these dependencies have never been investigated before. Since the number of our data was limited, the observed trends should be verified in a larger sample of patients and such a verification could take into account the suggestions for data analysis that we provide in this paper. Our data are in line with the earlier published research on MN firing characteristics post-stroke and support the conclusion that the MUs of the muscles at the non-paretic side are also affected and cannot be considered a suitable control for the MUs on the paretic side.
本文通过对11例中风后患者非患侧（受影响较小侧）进行相同分析，扩展了先前发表的关于患侧（受影响较大侧）运动神经元（MNs）超极化后电位（AHP）持续时间变化的研究观察结果。为受影响较大肌肉提供神经支配的患者MNs的估计AHP持续时间显著长于对照值，且这种延长随患者年龄和病程的增加而减小。为受影响较小肌肉提供神经支配的MNs，AHP持续时间对年龄的依赖性更接近对照数据，但离散度更大。然而，在中风后的短时间内，受影响较小的MNs的AHP持续时间估计值往往比对照组的长，而在长时间内则比对照组短。因此，我们的结果表明，两侧的脊髓MNs对脑卒中超极化后电位持续时间延长迅速做出反应，随着时间推移这种延长趋于正常化，这与功能恢复一致。这一观点与先前发表的关于中风后脑半球变化的研究一致。据我们所知，这些相关性以前从未被研究过。由于我们的数据数量有限，观察到的趋势应在更大的患者样本中进行验证，并且这种验证可以考虑我们在本文中提供的数据分析建议。我们的数据与先前发表的关于中风后MNs放电特征的研究一致，并支持以下结论：非患侧肌肉的运动单位（MUs）也受到影响，不能被视为患侧MUs的合适对照。
