Departamento de Pediatria,Instituto Nacional de Saúde da Mulher,Criança e Adolescente Fernandes Figueira,Fundação Oswaldo Cruz,Rio de Janeiro,Brazil.
Laboratório de Epidemiologia Clínica,Instituto Nacional de Infectologia Evandro Chagas,Fundação Oswaldo Cruz,Rio de Janeiro,Brazil.
Epidemiol Infect. 2018 Feb;146(3):359-366. doi: 10.1017/S0950268817003119. Epub 2018 Jan 17.
In 2007-2008, the city of Rio de Janeiro underwent an epidemiological change, with increases in the incidence in children and in severe forms of dengue. To describe the clinical profile and spatial distribution of dengue we performed an ecological study based on dengue surveillance data using the Brazilian classification (2005): dengue fever, dengue haemorrhagic fever (DHF) and dengue with complications. χ 2 test was used to describe the clinical and socio-demographic variables (P < 0.05). Spatial distribution of incidence and case-fatality was explored with thematic maps, Moran and Geary indices (P < 0.05). Of the total of 151 527 dengue cases, 38 808 met the inclusion criteria; 42.4% <18 years; 22.9% dengue with complications and 2.7% DHF. Case-fatality was higher in infants (1.4%) and in DHF (7.7%). Bleeding was more frequent in adolescents and adults while plasma leakage was more common in preschoolers and schoolchildren. The highest incidence was found in the West Zone of the city, in a different area from that of the worst case-fatality (P < 0.05). Although the incidence of DHF was higher in schoolchildren, infants showed higher case-fatality. The area with the highest case-fatality did not present the highest incidence, which suggests problems in the organization of health services.
2007-2008 年,里约热内卢市发生了一次流行病学变化,儿童病例和重症登革热病例有所增加。为了描述登革热的临床特征和空间分布,我们开展了一项基于登革热监测数据的生态研究,采用了巴西分类法(2005 年):登革热、登革出血热(DHF)和伴有并发症的登革热。采用卡方检验描述临床和社会人口学变量(P<0.05)。利用专题地图、莫兰和盖尔指数探索发病率和病死率的空间分布(P<0.05)。在总共 151527 例登革热病例中,有 38808 例符合纳入标准;42.4%<18 岁;22.9%伴有并发症,2.7%为 DHF。婴儿病死率较高(1.4%),DHF 病死率较高(7.7%)。青少年和成年人更容易出现出血,而幼儿和学童更容易出现血浆渗漏。城市西区的发病率最高,与病死率最高的地区不同(P<0.05)。尽管学龄儿童的 DHF 发病率较高,但婴儿的病死率更高。病死率最高的地区发病率并不高,这表明卫生服务的组织存在问题。