双嘧达莫加曲克芦丁与单用曲克芦丁在大脑中动脉闭塞后减少梗死方面的比较
Dipyridamole plus Triflusal versus Triflusal Alone in Infarct Reduction after Middle Cerebral Artery Occlusion.
作者信息
Amtul Zareen, Haque Wasimul, Cechetto David F
机构信息
Anatomy and Cell Biology Department, The University of Western Ontario, London, Ontario, Canada.
Kardiatech Inc., Edmonton, Alberta, Canada.
出版信息
J Stroke Cerebrovasc Dis. 2018 May;27(5):1283-1287. doi: 10.1016/j.jstrokecerebrovasdis.2017.12.013. Epub 2018 Jan 12.
BACKGROUND AND PURPOSE
The objective of this work is to study the dose-dependent effect of combination therapy with dipyridamole and triflusal over that of triflusal alone on infarct size after middle cerebral artery occlusion (MCAO) ischemia.
MATERIALS AND METHODS
Male Wistar rats were subjected to a permanent MCAO in the right hemisphere. Rats received triflusal alone and with dipyridamole via oral route. Three days after surgery, infarct volumes were measured.
RESULTS
The lower dose regime of triflusal (10 mg/kg) and dipyridamole (200 mg/kg) caused the greatest decrease in infarct size compared with higher dose regime of triflusal (30 mg/kg) and dipyridamole (200 mg/kg) (P <.01), triflusal (30 mg/kg) alone (P <.07), and vehicle-treated controls.
CONCLUSIONS
The lower dose combination of dipyridamole and triflusal appears to be more effective than triflusal alone after MCAO-induced cerebral ischemia. Therefore, there is a strong rationale to continue to examine the protective effects of triflusal and dipyridamole after cerebral ischemia.
背景与目的
本研究旨在探讨双嘧达莫与曲氟尿苷联合治疗与单独使用曲氟尿苷相比，对大脑中动脉闭塞（MCAO）缺血后梗死灶大小的剂量依赖性影响。
材料与方法
雄性Wistar大鼠右侧大脑半球接受永久性MCAO手术。大鼠通过口服途径单独接受曲氟尿苷以及与双嘧达莫联合用药。术后三天测量梗死体积。
结果
与曲氟尿苷高剂量组（30mg/kg）和双嘧达莫（200mg/kg）、单独使用曲氟尿苷（30mg/kg）以及溶剂处理的对照组相比，曲氟尿苷低剂量组（10mg/kg）和双嘧达莫（200mg/kg）导致梗死灶大小的减小最为显著（P＜0.01）。
结论
在MCAO诱导的脑缺血后，双嘧达莫与曲氟尿苷的低剂量联合用药似乎比单独使用曲氟尿苷更有效。因此，有充分的理由继续研究曲氟尿苷和双嘧达莫在脑缺血后的保护作用。
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