Kelvin F M, Gramm H F, Gluck W L, Lokich J J
AJR Am J Roentgenol. 1986 Jan;146(1):39-43. doi: 10.2214/ajr.146.1.39.
Floxuridine (5-FUDR) is an antipyrimidine used in the treatment of metastatic colorectal carcinoma. Bowel toxicity, manifested predominantly by diarrhea and abdominal pain, is one of the main complications of 5-FUDR therapy. Six patients who had received 5-FUDR infusion either by hepatic arterial or systemic intravenous routes subsequently developed severe diarrhea and were evaluated by small-bowel series. Radiographic changes were largely confined to the ileum. In four of six patients, the entire ileum or its more distal part was markedly narrowed. In the other two patients, changes consisted of thickening or effacement of the mucosal folds in the distal ileum. The symptoms of all six patients resolved after discontinuation of 5-FUDR therapy. This was accompanied by improvement in the radiographic appearance of the ileum in three patients who underwent a subsequent small-bowel series. The finding of reversible ileal changes, particularly extensive or segmental narrowing, seems to be a characteristic radiographic feature of bowel toxicity due to infusional 5-FUDR delivered by either the intraarterial or the systemic route.
氟尿苷（5-氟脱氧尿苷）是一种用于治疗转移性结直肠癌的抗嘧啶类药物。肠道毒性主要表现为腹泻和腹痛，是5-氟尿苷治疗的主要并发症之一。6例通过肝动脉或全身静脉途径接受5-氟尿苷输注的患者随后出现严重腹泻，并接受了小肠造影检查。影像学改变主要局限于回肠。6例患者中有4例，整个回肠或其更远端部分明显变窄。另外2例患者的改变包括回肠远端黏膜皱襞增厚或消失。5-氟尿苷治疗中断后，所有6例患者的症状均得到缓解。3例随后接受小肠造影检查的患者，其回肠的影像学表现也有所改善。由动脉内或全身途径输注5-氟尿苷导致的肠道毒性，其可逆性回肠改变，尤其是广泛性或节段性狭窄，似乎是一种典型的影像学特征。
