Kikindjanin V, Vukavić T, Oprić M, Novakov G
Allerg Immunol (Leipz). 1985;31(3):183-8.
The case of a 10 month-old girl with a history of recurrent urticaria and diarrhoea is presented. Immunological study was carried out and secretory component in sputum, duodenal juice and stool was not found, while IgA was detected. Peroral biopsy of intestinum was also carried out and histology revealed partial villous atrophy. Immunofluorescent staining showed only a few IgA and IgG producing cells scattered within the villous stroma, while the IgM producing cells were increased in number. Serum concentration of IgA, IgM and particularly IgG was increased. Both parents had measurable IgA in the serum, however, the secretory component was not detectable neither in mother nor in father. The deficiency of secretory component and deficiency of IgA producing cells in the jejunal villous stroma led to local immunodeficiency of the intestinal mucosa and that caused recurrent urticaria and diarrhoea in the girl presented.
本文介绍了一名10个月大、有复发性荨麻疹和腹泻病史的女孩的病例。进行了免疫学研究，在痰液、十二指肠液和粪便中未发现分泌成分，但检测到了IgA。还对肠道进行了经口活检，组织学显示部分绒毛萎缩。免疫荧光染色显示，只有少数产生IgA和IgG的细胞散在于绒毛基质中，而产生IgM的细胞数量增加。血清中IgA、IgM尤其是IgG的浓度升高。父母双方血清中均可检测到可测量的IgA，然而，母亲和父亲的分泌成分均无法检测到。空肠绒毛基质中分泌成分的缺乏和产生IgA细胞的缺乏导致肠道黏膜局部免疫缺陷，进而导致该女孩出现复发性荨麻疹和腹泻。
