Rodgers S E, Lloyd J V, Russell W J
Anaesth Intensive Care. 1985 Nov;13(4):355-61. doi: 10.1177/0310057X8501300404.
Platelet function was studied in CPD whole blood stored at 4 degrees C for one and three days and in platelet concentrates stored at room temperature for the same periods of time. Comparisons were made of platelet shape, nucleotide content, beta-thromboglobulin (beta TG) liberated during storage, and platelet aggregation in response to ADP, collagen, sodium arachidonate and ristocetin. It was found that in whole blood the shape of the platelets was less discoid than in platelet concentrates. However, platelet aggregation in response to ADP, collagen, and sodium arachidonate was preserved better in whole blood than in platelet concentrates. Platelet nucleotides were the same in whole blood as in platelet concentrates, but the plasma levels of beta TG were less in whole blood. The results show that as judged by aggregation, beta TG release and nucleotide content, platelets from whole blood were at least as functional as those from platelet concentrates. However, platelets from whole blood had lost their discoid shape, which suggests that they would have a short survival in the circulation.
研究了在4℃储存1天和3天的CPD全血以及在室温下储存相同时间的血小板浓缩物中的血小板功能。比较了血小板形状、核苷酸含量、储存期间释放的β-血小板球蛋白（βTG）以及对ADP、胶原蛋白、花生四烯酸钠和瑞斯托菌素的血小板聚集情况。结果发现，全血中血小板的形状比血小板浓缩物中的更不像盘状。然而，全血中对ADP、胶原蛋白和花生四烯酸钠的血小板聚集保存得比血小板浓缩物中更好。全血中的血小板核苷酸与血小板浓缩物中的相同，但全血中βTG的血浆水平较低。结果表明，从聚集、βTG释放和核苷酸含量判断，全血中的血小板功能至少与血小板浓缩物中的血小板一样好。然而，全血中的血小板已失去其盘状形状，这表明它们在循环中的存活时间会很短。
