Sehgal Vishal, Childress Richard
University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
J Transl Int Med. 2017 Dec 29;5(4):235-239. doi: 10.1515/jtim-2017-0039. eCollection 2017 Dec.
Immune check point inhibitors have revolutionized the treatment of metastatic malignancies. They are a promising area in oncology and more drugs are likely to be available in the coming years. Along with the promise of better response oncologically, there is an increased incidence of endocrinopathies related to autoimmunity. This case report illustrates the dramatic development of hypothyroidism in a patient with underlying subclinical hyperthyroidism. It also suggests the potential pretreatment predictors of endocrinopathies related to these immune check point inhibitors.
免疫检查点抑制剂彻底改变了转移性恶性肿瘤的治疗方式。它们是肿瘤学中一个很有前景的领域，未来几年可能会有更多药物问世。除了在肿瘤学上有望获得更好的反应外，与自身免疫相关的内分泌病发病率也有所增加。本病例报告阐述了一名患有潜在亚临床甲状腺功能亢进症的患者发生甲状腺功能减退症的显著过程。它还提示了与这些免疫检查点抑制剂相关的内分泌病的潜在预处理预测因素。
