Rizzetti Danize Aparecida, Quadros Janayna Rodembuch Borba, Ribeiro Bruna Esmerio, Callegaro Letícia, Veppo Aline Arebalo, Wiggers Giulia Alessandra, Peçanha Franck Maciel
. Curso de Fisioterapia, Universidade Federal do Pampa - UNIPAMPA - Uruguaiana (RS) Brasil.
. Residência Multiprofissional em Saúde, Universidade Federal do Pampa - UNIPAMPA - Uruguaiana (RS) Brasil.
J Bras Pneumol. 2017 Nov-Dec;43(6):409-415. doi: 10.1590/S1806-37562017000000088.
To determine whether different levels of CPAP improve the lung volumes and capacities of healthy subjects immersed in water.
This was a randomized clinical trial, conducted between April and June of 2016, involving healthy female volunteers who were using oral contraceptives. Three 20-min immersion protocols were applied: control (no CPAP); CPAP5 (CPAP at 5 cmH2O); and CPAP10 (CPAP at 10 cmH2O). We evaluated HR, SpO2, FVC, FEV1, the FEV1/FVC ratio, peak expiratory flow rate (PEFR), and FEF25-75%) at three time points: pre-immersion; 10 min after immersion; and 10 min after the end of each protocol.
We evaluated 13 healthy volunteers. The CPAP10 protocol reversed the restrictive pattern of lung function induced by immersion in water, maintaining pulmonary volumes and capacities for a longer period than did the CPAP5 protocol.
When the hemodynamic change causing a persistent lung disorder, only the application of higher positive pressures is effective in maintaining long-term improvements in the pulmonary profile.
确定不同水平的持续气道正压通气(CPAP)是否能改善浸入水中的健康受试者的肺容积和肺容量。
这是一项随机临床试验,于2016年4月至6月进行,纳入正在使用口服避孕药的健康女性志愿者。应用了三种20分钟的浸入方案:对照组(无CPAP);CPAP5(5 cmH2O的CPAP);和CPAP10(10 cmH2O的CPAP)。我们在三个时间点评估心率(HR)、血氧饱和度(SpO2)、用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、FEV1/FVC比值、呼气峰值流速(PEFR)和25%-75%用力呼气流量(FEF25-75%):浸入前;浸入后10分钟;以及每个方案结束后10分钟。
我们评估了13名健康志愿者。CPAP10方案逆转了因浸入水中引起的限制性肺功能模式,与CPAP5方案相比,能在更长时间内维持肺容积和肺容量。
当血流动力学变化导致持续性肺部疾病时,只有应用较高的正压才能有效维持肺部状况的长期改善。