Franchimont P, Demoulin A, Verstraelen-Proyard J, Hazee-Hagelstein M T, Tunbridge W M
J Reprod Fertil Suppl. 1979(26):123-33.
Human seminal plasma obtained by centrifugation of human semen contains a factor capable of selectively inhibiting the secretion of FSH both in vivo (reduction of the levels of FSH in rats 24 h after castration) and in vitro (reduction of the FSH released by LH-RH in rat pituitary cell culture). This effect is not due to testosterone, oestradiol-17 beta or progesterone present in the active fractions. The factor has the characteristics of a protein in that its biological activity is destroyed by heat and trypsin digestion. It does not resemble androgen-binding protein. The biological action is not completely specific for FSH as inhibition of LH can be seen with doses usually higher than those which produce inhibition of FSH alone. There is no effect on TSH or prolactin levels in vitro. The factor clearly acts on the release and synthesis of gonadotrophins by gonadotrophs but an effect on the hypothalamus is not excluded. This factor fits the definition of inhibin.
通过离心人类精液获得的人类精浆含有一种因子，该因子能够在体内（阉割后24小时降低大鼠体内促卵泡激素水平）和体外（降低大鼠垂体细胞培养中促黄体激素释放激素释放的促卵泡激素）选择性抑制促卵泡激素的分泌。这种作用并非由活性组分中存在的睾酮、雌二醇-17β或孕酮引起。该因子具有蛋白质的特性，因为其生物活性会被加热和胰蛋白酶消化破坏。它与雄激素结合蛋白不同。其生物作用并非完全特异性针对促卵泡激素，因为通常高于单独产生促卵泡激素抑制作用的剂量时，可观察到对促黄体激素的抑制。体外对促甲状腺激素或催乳素水平无影响。该因子显然作用于促性腺细胞释放和合成促性腺激素，但不排除对下丘脑有影响。这种因子符合抑制素的定义。
