Dynamic Contrast-Enhanced MRI.

Dynamic contrast-enhanced MRI in pre-clinical imaging allows the in-vivo monitoring of vascular, physiological properties in normal and diseased tissue. There is considerable variation in the methods employed owing to the different questions that can be asked and answered about the physiologic alterations as well as morphologic changes in tissue. Here we review the typical decisions in the design and execution of a dynamic contrast-enhanced MRI study in mice although the findings can easily be transferred to other species. Emphasis is placed on highlighting the many pitfalls that wait for the unaware pre-clinical MRI practitioner and that go often unmentioned in the abundant literature dealing with dynamic contrast-enhanced MRI in animal models.