可持续的 HandaPhos-ppm 钯技术用于温和条件下水中的无铜 Sonogashira 偶联反应。
Sustainable HandaPhos-ppm Palladium Technology for Copper-Free Sonogashira Couplings in Water under Mild Conditions.
机构信息
Department of Chemistry, University of Louisville , 2320 South Brook Street, Louisville, Kentucky 40292, United States.
Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.
出版信息
Org Lett. 2018 Feb 2;20(3):542-545. doi: 10.1021/acs.orglett.7b03621. Epub 2018 Jan 17.
Complexation of ca. 1000 ppm Pd(OAc) with the ligand HandaPhos (1-1.5:1) leads to a precatalyst that efficiently mediates Sonogashira couplings in aqueous nanomicelles under very mild conditions. Neither copper nor organic solvent is required in the reaction medium, and the product can be isolated directly from the reaction flask, leaving behind a reaction mixture that can be recycled without additional additives.
约 1000ppm 的 Pd(OAc)与配体 HandaPhos（1-1.5:1）络合，得到的前催化剂可在非常温和的条件下在水相纳米胶束中高效介导 Sonogashira 偶联反应。反应介质中既不需要铜也不需要有机溶剂，产物可直接从反应瓶中分离出来，留下的反应混合物无需添加额外的添加剂即可回收利用。
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