Hong C, Li J Y, Chen R K, Liu C L, Wang X N, Qing S M, Su X F, Zhang N F
State Key Laboratory of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Diseases, National Research Center of Clinical Medicine, Guangzhou 510120, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2018 Jan 12;41(1):37-40. doi: 10.3760/cma.j.issn.1001-0939.2018.01.010.
To investigate the correlation of peripheral venous oxygen saturation (SpvO(2)) with mixed venous oxygen saturation (SvO(2)), pulmonary vascular resistance (PVR) and cardiac index (CI) in patients with pulmonary hypertension (PH), in order to predict these parameters using SpvO(2) and assess the prognosis of patients. Hospitalized patients diagnosed with PH by right heart catheterization in the Guangzhou Institute of Respiratory Diseases from July 2015 to October 2016 were retrospectively analyzed. Parameters during the right heart catheterization, including SvO(2,)SpvO(2,)cardiac output (CO) and mean pulmonary arterial pressure (mPAP) were recorded, while CI, PVR and other parameters were indirectly calculated. The correlation between SpvO(2) and SvO(2,)CO, CI, mPAP, PVR and other parameters were respectively analyzed and compared between groups. A total of 77 PH patients were selected, which comprised of 39 males and 38 females. The results revealed that SpvO(2) was correlated positively with SvO(2,)CI and PaO(2) (<0.05), but negatively with PVR, total pulmonary resistance (TPR), systemic vascular resistance, right atrial diameter and right ventricular diameter (<0.05). In the group with SpvO(2) <65%, the dilation of the right atrium and right ventricle was more significant, the WHO heart function grade was worse, CI, systemic systolic pressure and mean systemic pressure were lower, and PVR and TPR were higher, as compared to those in the group with SpvO(2) ≥65%. (<0.05). There was good consistency between SpvO(2) and SvO(2). Furthermore, SpvO(2) could indirectly reflect the CI, PVR and changes in right heart structure of PH patients, providing reference for the clinical prediction of CI and PVR, as well as the prognosis of PH patients, through the use of SpvO(2). Low SpvO(2) indicated a severe condition and poor prognosis.
为研究肺动脉高压（PH）患者外周静脉血氧饱和度（SpvO₂）与混合静脉血氧饱和度（SvO₂）、肺血管阻力（PVR）和心脏指数（CI）之间的相关性，以便用SpvO₂预测这些参数并评估患者预后。回顾性分析2015年7月至2016年10月在广州医科大学附属第一医院广州呼吸疾病研究所通过右心导管检查确诊为PH的住院患者。记录右心导管检查期间的参数，包括SvO₂、SpvO₂、心输出量（CO）和平均肺动脉压（mPAP），同时间接计算CI、PVR等参数。分别分析并比较SpvO₂与SvO₂、CO、CI、mPAP、PVR等参数之间的相关性及组间差异。共入选77例PH患者，其中男性39例，女性38例。结果显示，SpvO₂与SvO₂、CI和动脉血氧分压（PaO₂）呈正相关（P<0.05），与PVR、总肺阻力（TPR）、体循环血管阻力、右心房内径和右心室内径呈负相关（P<0.05）。SpvO₂<65%组与SpvO₂≥65%组相比，右心房和右心室扩大更明显，世界卫生组织心功能分级更差，CI、体循环收缩压和平均体循环压力更低，PVR和TPR更高（P<0.05）。SpvO₂与SvO₂具有良好的一致性。此外，SpvO₂可间接反映PH患者的CI、PVR及右心结构变化，通过检测SpvO₂可为临床预测CI和PVR以及评估PH患者预后提供参考。低SpvO₂提示病情严重、预后不良。
