Mihcin Senay, Melzer Andreas
a Institute for Medical Science and Technology , Universities Dundee & St. Andrews Ninewells Hospital and Medical School , Dundee , UK.
b Division Medical Technology, Institute for Medical Science and Technology , Universities Dundee & St. Andrews Ninewells Hospital and Medical School , Dundee , UK.
Minim Invasive Ther Allied Technol. 2018 Feb;27(1):41-50. doi: 10.1080/13645706.2017.1414063. Epub 2018 Jan 18.
Focused ultrasound (FUS/HIFU) relies on ablation of pathological tissues by delivering a sufficiently high level of acoustic energy in situ of the human body. Magnetic Resonance guided FUS (MRgFUS/HIFU) and Ultrasound guided (USgFUS/HIFU) are image guided techniques combined with therapeutic FUS for monitoring purposes. The principles and technologies of FUS/HiFU are described in this paper including the basics of MR guidance techniques and MR temperature mapping. Clinical applications of FUS/HIFU gained CE and FDA approvals for the treatment of various benign and few malignant lesions in the last two decades. Current technical limitations of ultrasound guided and MRI guided Focused Ultrasound, as well as adverse effects for the application of this technique are outlined including challenges of ablating moving organs (liver and kidney). An outlook to possible applications is provided; exampling clinical trials discussing future options.
聚焦超声（FUS/HIFU）通过在人体原位传递足够高的声能来消融病理组织。磁共振引导聚焦超声（MRgFUS/HIFU）和超声引导聚焦超声（USgFUS/HIFU）是与治疗性聚焦超声相结合用于监测目的的图像引导技术。本文描述了聚焦超声/高强度聚焦超声（FUS/HiFU）的原理和技术，包括磁共振引导技术和磁共振温度映射的基础知识。在过去二十年中，聚焦超声/高强度聚焦超声（FUS/HIFU）的临床应用获得了CE和FDA批准，用于治疗各种良性和少数恶性病变。概述了超声引导和磁共振成像引导聚焦超声的当前技术局限性，以及该技术应用的不良反应，包括消融运动器官（肝脏和肾脏）的挑战。提供了可能应用的展望；以讨论未来选择的临床试验为例。
