Siedek Florian, Yeo Sin Yuin, Heijman Edwin, Grinstein Olga, Bratke Grischa, Heneweer Carola, Puesken Michael, Persigehl Thorsten, Maintz David, Grüll Holger
Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany.
Rofo. 2019 Jun;191(6):522-530. doi: 10.1055/a-0817-5645. Epub 2019 Jan 10.
Extracorporeal high-intensity focused ultrasound (HIFU) is a promising method for the noninvasive thermal ablation of benign and malignant tissue. Current HIFU treatments are performed under ultrasound (US-HIFU) or magnetic resonance (MR-HIFU) image guidance offering integrated therapy planning, real-time control (spatial and temperature guidance) and evaluation.
This review is based on publications in peer-reviewed journals addressing thermal ablation using HIFU and includes our own clinical results as well. The technical background of HIFU is explained with an emphasis on MR-HIFU applications. A brief overview of the most commonly performed CE-approved clinical applications for MR-HIFU is given.
Over the last decade, several HIFU-based applications have received clinical approval in various countries. In particular, MR-HIFU is now approved for the clinical treatment of uterine fibroids, palliation of bone pain, ablation of the prostate and treatment of essential tremor as a first neurological application.
MR-HIFU is a patient-friendly noninvasive method for thermal ablation which has received clinical approval for several applications. Overall, clinical data demonstrate treatment efficacy, safety and cost efficiency.
· HIFU is a promising technique for noninvasive thermal ablation of tissue.. · HIFU is typically performed under image guidance using either diagnostic ultrasound (US-HIFU) or MRI (MR-HIFU).. · The preferred image guidance modality depends on the application.. · MR guidance offers improved soft-tissue contrast for treatment planning, near real-time and noninvasive temperature monitoring and post-interventional therapy evaluation.. · MR-HIFU is CE-approved for treatment of uterine fibroids, alleviation of bone pain, prostate tissue ablation and treatment of essential tremor..
· Siedek F, Yeo S, Heijman E et al. Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1). Fortschr Röntgenstr 2019; 191: 522 - 530.
体外高强度聚焦超声（HIFU）是一种用于良性和恶性组织无创热消融的有前景的方法。当前的HIFU治疗在超声（US-HIFU）或磁共振（MR-HIFU）图像引导下进行，可提供综合治疗规划、实时控制（空间和温度引导）及评估。
本综述基于同行评审期刊中关于使用HIFU进行热消融的出版物，并纳入了我们自己的临床结果。对HIFU的技术背景进行了解释，重点是MR-HIFU的应用。简要概述了MR-HIFU最常见的已获CE批准的临床应用。
在过去十年中，几种基于HIFU的应用已在各国获得临床批准。特别是，MR-HIFU目前已被批准用于子宫肌瘤的临床治疗、缓解骨痛、前列腺消融以及作为首个神经学应用治疗特发性震颤。
MR-HIFU是一种对患者友好的无创热消融方法，已在多种应用中获得临床批准。总体而言，临床数据证明了其治疗效果、安全性和成本效益。
· HIFU是一种用于组织无创热消融的有前景的技术。· HIFU通常在图像引导下使用诊断超声（US-HIFU）或MRI（MR-HIFU）进行。· 首选的图像引导方式取决于应用。· MR引导为治疗规划提供了更好的软组织对比度、近实时和无创温度监测以及介入后治疗评估。· MR-HIFU已获CE批准用于子宫肌瘤治疗、缓解骨痛、前列腺组织消融和特发性震颤治疗。
· Siedek F, Yeo S, Heijman E等。磁共振引导的高强度聚焦超声（MR-HIFU）：技术背景和当前临床应用概述（第1部分）。Fortschr Röntgenstr 2019; 191: 522 - 530。
