Collagen and Calcium Binding EGF Domains 1 (CCBE1) in cancer - a new role past lymphatics?
作者信息
Mesci Aruz, Liu Stanley K
机构信息
Sunnybrook Research Institute, Toronto, Canada; Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, Canada.
出版信息
Oncoscience. 2017 Nov 9;4(11-12):168-169. doi: 10.18632/oncoscience.376. eCollection 2017 Nov.
Abstract
摘要
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本文引用的文献
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Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.有效的淋巴管生成生长因子 VEGF-C 的激活需要 VEGF-C 的 C 末端结构域和 CCBE1 的 N 末端结构域。
Sci Rep. 2017 Jul 7;7(1):4916. doi: 10.1038/s41598-017-04982-1.
2
Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis.在人类乳腺癌中，miR-330-3p靶向CCBE1会促进转移。
Br J Cancer. 2017 May 9;116(10):1350-1357. doi: 10.1038/bjc.2017.105. Epub 2017 Apr 18.
3
CCBE1 promotes GIST development through enhancing angiogenesis and mediating resistance to imatinib.CCBE1通过增强血管生成和介导对伊马替尼的耐药性来促进胃肠道间质瘤的发展。
Sci Rep. 2016 Aug 10;6:31071. doi: 10.1038/srep31071.
4
Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.CCBE1 蛋白的功能剖析：胶原重复结构域的关键需求
Circ Res. 2015 May 8;116(10):1660-9. doi: 10.1161/CIRCRESAHA.116.304949. Epub 2015 Mar 26.
5
Collagen and calcium-binding EGF domains 1 is frequently inactivated in ovarian cancer by aberrant promoter hypermethylation and modulates cell migration and survival.胶原蛋白和钙结合表皮生长因子结构域 1 常因启动子异常甲基化失活，调节细胞迁移和存活。
Br J Cancer. 2010 Jan 5;102(1):87-96. doi: 10.1038/sj.bjc.6605429. Epub 2009 Nov 24.
6
Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans.CCBE1 基因突变导致人类全身性淋巴管发育不良。
Nat Genet. 2009 Dec;41(12):1272-4. doi: 10.1038/ng.484.
7
Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting.胚胎淋巴管生成和静脉芽生需要Ccbe1。
Nat Genet. 2009 Apr;41(4):396-8. doi: 10.1038/ng.321. Epub 2009 Mar 15.
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Scanning copy number and gene expression on the 18q21-qter chromosomal region by the systematic multiplex PCR and reverse transcription-PCR methods.通过系统多重聚合酶链反应和逆转录聚合酶链反应方法扫描18q21-qter染色体区域的拷贝数和基因表达。
Electrophoresis. 2007 Jun;28(12):1882-95. doi: 10.1002/elps.200700093.
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