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经人类造血干细胞宫内移植后，小鼠出现系统性多谱系嵌合体。

Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells.

机构信息

Eli and Edythe Broad Center of Regeneration Medicine, San Francisco, CA.

Department of Surgery, University of California, San Francisco, San Francisco, CA; and.

出版信息

Blood Adv. 2018 Jan 5;2(1):69-74. doi: 10.1182/bloodadvances.2017011585. eCollection 2018 Jan 9.

DOI:10.1182/bloodadvances.2017011585
PMID:29344586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5761626/
Abstract

IUHCT of human cord blood-derived CD34 cells into fetal NSG mice results in systemic multilineage engraftment with human cells.Preconditioning with in utero injection of an anti-c-Kit receptor antibody (ACK2) results in an improved rate of engraftment.

摘要

将人脐血来源的 CD34 细胞经 IUHCT 植入胎儿 NSG 小鼠可导致人细胞的系统性多谱系嵌合。预先经宫内注射抗 c-Kit 受体抗体（ACK2）预处理可提高嵌合率。

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本文引用的文献

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Complement Depletion Improves Human Red Blood Cell Reconstitution in Immunodeficient Mice.补体耗竭可改善免疫缺陷小鼠的人红细胞重建。
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Chronic graft-versus-host-disease in CD34(+)-humanized NSG mice is associated with human susceptibility HLA haplotypes for autoimmune disease.CD34(+)-人源化 NSG 小鼠中的慢性移植物抗宿主病与人类自身免疫性疾病易感 HLA 单倍型相关。
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In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.子宫内胎儿造血干细胞的耗竭可改善小鼠新生儿移植后的植入情况。
Blood. 2014 Aug 7;124(6):973-80. doi: 10.1182/blood-2014-02-550327. Epub 2014 May 30.
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Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation.在同种异体宫内造血细胞移植的犬模型中实现了稳定的长期混合嵌合体。
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Mfsd2a is critical for the formation and function of the blood-brain barrier.Mfsd2a对血脑屏障的形成和功能至关重要。
Nature. 2014 May 22;509(7501):507-11. doi: 10.1038/nature13324. Epub 2014 May 14.
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