O-糖基化修饰：糖酵解途径的关键调节因子。
O-GlcNAcylation: key regulator of glycolytic pathways.
机构信息
Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA.
出版信息
J Bioenerg Biomembr. 2018 Jun;50(3):189-198. doi: 10.1007/s10863-018-9742-3. Epub 2018 Jan 18.
Abstract
Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in cancer cells. This review summarizes our current understanding of how O-GlcNAcylation regulates glycolytic pathways and contributes to alterations in cancer cell metabolism.
摘要
O-GlcNAcylation 水平升高正成为大多数癌症的普遍特征。尽管 O-GlcNAcylation 可以调节许多细胞生物学途径，但最近的证据表明，它是包括癌细胞糖酵解在内的代谢途径的关键调节剂。这篇综述总结了我们目前对 O-GlcNAcylation 如何调节糖酵解途径以及如何促进癌细胞代谢改变的理解。
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