细胞外基质与创伤性脑损伤。
Extracellular matrix and traumatic brain injury.
机构信息
Laboratory of Developmental Neurobiology, Cell Biology and Physiology Center, NHLBI, NIH, Bethesda, MD, 20892-1603, USA.
出版信息
J Neurosci Res. 2018 Apr;96(4):573-588. doi: 10.1002/jnr.24151. Epub 2018 Jan 18.
Abstract
The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following traumatic brain injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.
摘要
大脑细胞外基质（ECM）在发育中和成年大脑中都起着至关重要的作用，为大脑提供结构支持并介导细胞间的相互作用。在这篇综述中，我们重点介绍 ECM 的主要成分以及它们在正常和受损大脑中的功能，并总结 ECM 成分的变化以及这些变化如何促进或抑制创伤性脑损伤（TBI）后的功能恢复。调节 ECM 组成以促进神经元存活、再生和轴突生长是 TBI 治疗的一个潜在治疗靶点。
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