在 3T 下对 17 个人类脑代谢物的横向弛豫时间常数 (T)进行体内估计。
In vivo estimation of transverse relaxation time constant (T ) of 17 human brain metabolites at 3T.
机构信息
Institute for Biomedical Engineering, University and ETH, Zurich, Switzerland.
Max Planck Institute for Biological Cybernetics, Tuebingen, Germany.
出版信息
Magn Reson Med. 2018 Aug;80(2):452-461. doi: 10.1002/mrm.27067. Epub 2018 Jan 17.
PURPOSE
The transverse relaxation times T of 17 metabolites in vivo at 3T is reported and region specific differences are addressed.
METHODS
An echo-time series protocol was applied to one, two, or three volumes of interest with different fraction of white and gray matter including a total number of 106 healthy volunteers and acquiring a total number of 128 spectra. The data were fitted with the 2D fitting tool ProFit2, which included individual line shape modeling for all metabolites and allowed the T calculation of 28 moieties of 17 metabolites.
RESULTS
The T of 10 metabolites and their moieties have been reported for the first time. Region specific T differences in white and gray matter enriched tissue occur in 16 of 17 metabolites examined including single resonance lines and coupled spin systems.
CONCLUSION
The relaxation time T is regions specific and has to be considered when applying tissue composition correction for internal water referencing. Magn Reson Med 80:452-461, 2018. © 2018 International Society for Magnetic Resonance in Medicine.
目的
报道了在 3T 下体内 17 种代谢物的横向弛豫时间 T，并解决了区域特异性差异。
方法
应用回波时间序列方案对一个、两个或三个感兴趣的容积进行检测，其中包括不同比例的白质和灰质，共有 106 名健康志愿者参与，并采集了 128 个光谱。数据采用 2D 拟合工具 ProFit2 进行拟合，该工具包括对所有代谢物进行单独的线形状建模，并允许对 17 种代谢物的 28 个部分进行 T 计算。
结果
首次报道了 10 种代谢物及其部分的 T 值。在所检查的 17 种代谢物中，白质和灰质富含组织的 T 存在区域特异性差异，包括单共振线和偶联自旋系统。
结论
当应用组织成分校正进行内水参考时，弛豫时间 T 是具有区域特异性的，必须加以考虑。磁共振医学 80:452-461, 2018。© 2018 国际磁共振学会。
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