INSERM U1073, Service de Physiologie Digestive, INSERM CIC 1404, Rouen, F-76000, France.
INSERM U1073, Service d'Hépato-Gastroentérologie, CHU Rouen, Rouen, France.
Neurogastroenterol Motil. 2018 Jun;30(6):e13291. doi: 10.1111/nmo.13291. Epub 2018 Jan 18.
The functional lumen imaging probe (EndoFLIP ) is a new technology that measures the distensibility of the anal canal represented by the anal distensibility index. The aims of this study were (i) to compare the anal distensibility index to anal pressure in a cohort of patients with fecal incontinence (FI) and (ii) to compare the diagnostic value of the EndoFLIP to that of high-resolution anorectal manometry (HRAM) in the same cohort of patients.
Eighty-three consecutive patients with FI who underwent EndoFLIP and HRAM assessments were enrolled. The diagnostic value of the EndoFLIP was compared to that of HRAM and agreement between EndoFLIP and HRAM data was assessed.
More than 70% of the patients diagnosed with anal deficiency at rest and/or during voluntary contractions by HRAM had the same diagnosis using the EndoFLIP . Two patients with higher distensibility indexes at rest had normal anal resting pressures. Sixteen patients with a normal EndoFLIP index (ie, normal distensibility index at rest and during voluntary contractions) had an abnormal HRAM result. Seven of these 16 patients (44%) had no sphincter lesion or neuropathic disorder that could explain an abnormal anal sphincter function.
CONCLUSIONS & INFERENCES: We demonstrated that the anal distensibility index and HRAM results are largely in agreement. We did, however, identify several discrepancies between the two techniques, indicating that they may be complementary.
功能腔内腔内成像探头（EndoFLIP）是一种新的技术，通过测量肛管的可扩张性来表示肛管扩张指数。本研究的目的是（i）比较肛管扩张指数与粪便失禁（FI）患者的肛管压力，（ii）比较 EndoFLIP 与相同患者队列中的高分辨率肛门直肠测压（HRAM）的诊断价值。
连续纳入 83 例接受 EndoFLIP 和 HRAM 评估的 FI 患者。将 EndoFLIP 的诊断价值与 HRAM 进行比较，并评估 EndoFLIP 和 HRAM 数据之间的一致性。
超过 70%的患者在 HRAM 下静息和/或自主收缩时被诊断为肛门缺陷，而使用 EndoFLIP 时也有相同的诊断结果。两名静息时扩张指数较高的患者有正常的肛管静息压力。16 名静息和自主收缩时 EndoFLIP 指数正常（即扩张指数正常）的患者 HRAM 结果异常。这 16 名患者中的 7 名（44%）没有可解释肛门括约肌功能异常的括约肌损伤或神经病变。
我们证明了肛管扩张指数和 HRAM 结果基本一致。然而，我们确实发现了两种技术之间的一些差异，表明它们可能是互补的。
