Department of Neurology, Northwestern University Feinberg School of Medicine, Abbott Hall, Chicago, IL 60607, USA.
Department of Neurology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60607, USA.
Future Oncol. 2018 Feb;14(4):391-407. doi: 10.2217/fon-2017-0255. Epub 2018 Jan 18.
Breast cancer is the most common malignancy among women and accounts for the second highest number of cancer-related deaths. With patients surviving longer due to advances in systemic control, the incidence of CNS involvement is increasing; however, the management of CNS metastases has not undergone parallel advancements. The blood-brain barrier limits the efficacy of most systemic chemotherapies, and the utilization of surgery and radiation beyond first-line therapy is limited. We will explore the recent developments in the medical management of breast cancer brain metastasis. Beyond traditional chemotherapy, we will also discuss targeted therapies and immunotherapies which may provide a survival benefit to this population and thus, offer further treatment options and a path for future research and treatment advances.
乳腺癌是女性中最常见的恶性肿瘤，也是癌症相关死亡人数第二多的疾病。由于系统控制方面的进步，患者的存活时间更长，因此中枢神经系统（CNS）受累的发生率增加；然而，CNS 转移的治疗并未取得平行进展。血脑屏障限制了大多数全身化疗的疗效，并且一线治疗以外的手术和放疗的应用也受到限制。我们将探讨乳腺癌脑转移的医学治疗的最新进展。除了传统的化疗，我们还将讨论靶向治疗和免疫疗法，这些疗法可能为这部分人群带来生存获益，从而提供更多的治疗选择，并为未来的研究和治疗进展开辟道路。
