Agrawal Anil Kumar, Pielka Ewa, Lipinski Artur, Jelen Michal, Kielan Wojciech, Agrawal Siddarth
1 2nd Department of General and Oncological Surgery, Wroclaw Medical University, Wroclaw, Poland.
2 Department of Pathology, Wroclaw Medical University, Wroclaw, Poland.
Tumour Biol. 2018 Jan;40(1):1010428317750929. doi: 10.1177/1010428317750929.
Breast cancer is the most commonly diagnosed cancer in Polish women. The expression of transcription nuclear factor kappa B, a key inducer of inflammatory response promoting carcinogenesis and cancer progression in breast cancer, is not well-established. We assessed the nuclear factor kappa B expression in a total of 119 invasive breast carcinomas and 25 healthy control samples and correlated this expression pattern with several clinical and pathologic parameters including histologic type and grade, tumor size, lymph node status, estrogen receptor status, and progesterone receptor status. The data used for the analysis were derived from medical records. An immunohistochemical analysis of nuclear factor kappa B, estrogen receptor, and progesterone receptor was carried out and evaluation of stainings was performed. The expression of nuclear factor kappa B was significantly higher than that in the corresponding healthy control samples. No statistical difference was demonstrated in nuclear factor kappa B expression in relation to age, menopausal status, lymph node status, tumor size and location, grade and histologic type of tumor, and hormonal status (estrogen receptor and progesterone receptor). Nuclear factor kappa B is significantly overexpressed in invasive breast cancer tissues. Although nuclear factor kappa B status does not correlate with clinicopathological findings, it might provide important additional information on prognosis and become a promising object for targeted therapy.
乳腺癌是波兰女性中最常被诊断出的癌症。转录核因子κB是促进乳腺癌发生和癌症进展的炎症反应的关键诱导因子，其表达情况尚未明确。我们评估了总共119例浸润性乳腺癌和25例健康对照样本中的核因子κB表达，并将这种表达模式与包括组织学类型和分级、肿瘤大小、淋巴结状态、雌激素受体状态和孕激素受体状态在内的几个临床和病理参数相关联。用于分析的数据来自医疗记录。对核因子κB、雌激素受体和孕激素受体进行了免疫组织化学分析，并对染色进行了评估。核因子κB的表达明显高于相应的健康对照样本。在核因子κB表达与年龄、绝经状态、淋巴结状态、肿瘤大小和位置、肿瘤分级和组织学类型以及激素状态（雌激素受体和孕激素受体）之间未显示出统计学差异。核因子κB在浸润性乳腺癌组织中明显过表达。虽然核因子κB状态与临床病理结果无关，但它可能为预后提供重要的额外信息，并成为有前景的靶向治疗对象。
