Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, Naples, Italy.
Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.
J Leukoc Biol. 2018 Mar;103(3):457-464. doi: 10.1002/JLB.3MR0717-292R. Epub 2017 Dec 15.
Chronic inflammation is a well-known tumor-enabling capacity, which allows nascent tumors to acquire all the hallmark capabilities, including the escape from immunosurveillance. Soluble and cellular inflammatory mediators constitute the complex network of the tumor microenvironment, in which tumors grow and with which constantly interact. Myeloid cells (e.g., tumor associated macrophages) are pivotal players of the tumor microenvironment and are characterized by plasticity, which consists of the ability to acquire distinct phenotypes in response to the microenvironment in which they reside. Neutrophils are emerging as important players of tumor microenvironment, given their heterogeneity and plasticity. Increasing evidence suggests a dual role for neutrophils in modulating tumor behavior and highlights the need for a reassessment of neutrophil functions in cancer initiation and progression.
慢性炎症是一种众所周知的肿瘤促进能力，它使新生肿瘤获得所有标志性特征，包括逃避免疫监视。可溶性和细胞炎性介质构成了肿瘤微环境的复杂网络，肿瘤在其中生长并与之不断相互作用。髓系细胞（如肿瘤相关巨噬细胞）是肿瘤微环境的关键参与者，其特征是可塑性，即能够根据其所处的微环境获得不同的表型。鉴于中性粒细胞的异质性和可塑性，它们正在成为肿瘤微环境的重要参与者。越来越多的证据表明中性粒细胞在调节肿瘤行为方面具有双重作用，并强调需要重新评估中性粒细胞在癌症发生和发展中的功能。
