Department of NanoEngineering, University of California, San Diego , La Jolla, California 92093, United States.
Division of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University , Box 124, SE-221 00 Lund, Sweden.
ACS Appl Mater Interfaces. 2018 Feb 14;10(6):5331-5339. doi: 10.1021/acsami.7b18312. Epub 2018 Jan 31.
Polycarbonates are widely used in food packages, drink bottles, and various healthcare products such as dental sealants and tooth coatings. However, bisphenol A (BPA) and phosgene used in the production of commercial polycarbonates pose major concerns to public health safety. Here, we report a green pathway to prepare BPA-free polycarbonates (BFPs) by thermal ring-opening polymerization and photopolymerization. Polycarbonates prepared from two cyclic carbonates in different mole ratios demonstrated tunable mechanical stiffness, excellent thermal stability, and high optical transparency. Three-dimensional (3D) printing of the new BFPs was demonstrated using a two-photon laser direct writing system and a rapid 3D optical projection printer to produce structures possessing complex high-resolution geometries. Seeded C3H10T1/2 cells also showed over 95% viability with potential applications in biological studies. By combining biocompatible BFPs with 3D printing, novel safe and high-performance biomedical devices and healthcare products could be developed with broad long-term benefits to society.
聚碳酸酯被广泛应用于食品包装、饮料瓶以及各类医疗产品，如牙釉质封闭剂和牙齿涂层。然而，商业聚碳酸酯生产过程中使用的双酚 A（BPA）和光气对公共卫生安全构成了重大威胁。在这里，我们报告了一种通过热开环聚合和光聚合制备无 BPA 聚碳酸酯（BFPs）的绿色途径。由两种环状碳酸酯以不同摩尔比制备的聚碳酸酯具有可调的机械硬度、优异的热稳定性和高光学透明度。新的 BFPs 可通过双光子激光直写系统和快速 3D 光学投影打印机进行 3D 打印，从而制造具有复杂高分辨率几何形状的结构。种子细胞 C3H10T1/2 的存活率也超过 95%，具有在生物研究中的潜在应用。通过将生物相容性的 BFPs 与 3D 打印相结合，可以开发出新型安全且高性能的生物医学设备和医疗产品，为社会带来广泛的长期利益。
