单纯疱疹病毒相关性前葡萄膜炎的临床特征。
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis.
机构信息
a Oogcentrum Noord Holland , Heerhugowaard , The Netherlands.
b Department of Ophthalmology and Visual Science , Tokyo Medical and Dental University , Tokyo , Japan.
出版信息
Ocul Immunol Inflamm. 2018;26(3):333-337. doi: 10.1080/09273948.2017.1420806. Epub 2018 Jan 18.
PURPOSE
The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis.
METHODS
The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included.
RESULTS
It was observed that HSV anterior uveitis is mostly an acute unilateral disease mainly occurring in middle-aged people with a predominance in females. The incidence of keratitis in HSV is between 33 and 41%. High intraocular pressure is frequently observed and ranged from 46 to 90%. Sectorial iris atrophy may be absent, especially early in the disease.
CONCLUSION
The clinical characteristics of HSV anterior uveitis can mimic other viral and non-infectious anterior uveitis entities especially at onset. Aqueous humor analysis for PCR and GWC can be useful in case of suspected viral uveitis.
目的
本研究旨在描述经聚合酶链反应（PCR）和/或房水 Goldmann-Witmer 系数证实的单纯疱疹病毒（HSV）前葡萄膜炎的临床特征。
方法
对通过 PCR 和/或房水 Goldmann-Witmer 系数确诊为单纯疱疹病毒前葡萄膜炎的相关文献进行了回顾。纳入了来自欧洲的三项研究和来自日本的一项研究。
结果
观察到 HSV 前葡萄膜炎主要为急性单侧疾病，主要发生在中年人群中，女性居多。HSV 相关性角膜炎的发生率在 33%至 41%之间。高眼压频繁发生，范围在 46%至 90%之间。扇形虹膜萎缩可能不存在，尤其是在疾病早期。
结论
HSV 前葡萄膜炎的临床特征可模仿其他病毒性和非感染性前葡萄膜炎，尤其是在疾病早期。对于疑似病毒性葡萄膜炎，房水分析进行 PCR 和 GWC 可能有用。
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