Departments of Kinesiology and Mechanical and Industrial Engineering, University of Massachusetts-Amherst, Amherst, MA.
Exerc Sport Sci Rev. 2018 Apr;46(2):121-128. doi: 10.1249/JES.0000000000000141.
Pain has an important physiologic role and acts with or stimulates motor system adaptations to protect tissue from threats of damage. Although clinically beneficial, removing the protective pain response may have negative consequence in osteoarthritis, a mechanically mediated disease. We hypothesize motor system adaptations to joint pain and its treatment may impact osteoarthritis progression, thereby limiting efficacy of pain therapies.
疼痛具有重要的生理作用，它与运动系统相互作用或刺激运动系统适应，以保护组织免受损伤威胁。尽管在临床上有益，但在机械介导的疾病骨关节炎中，去除这种保护性疼痛反应可能会产生负面影响。我们假设关节疼痛及其治疗的运动系统适应可能会影响骨关节炎的进展，从而限制疼痛治疗的疗效。
