Taşcă C, Stefăneanu L, Simionescu L, Medeşan C
Morphol Embryol (Bucur). 1985 Oct-Dec;31(4):261-8.
The authors study by means of immunoperoxidase method the pattern of thyroglobulin, triiodothyronine and thyroxine distribution in 58 cases of thyroid disorders: 15 euthyroid goiters, 10 Graves' disease, 7 Hashimoto's thyroiditis, 11 folliculo-papillary carcinomas (6 primary tumors and 5 lymph node metastases), 8 follicular carcinomas, 4 anaplastic carcinomas and 3 medullary carcinomas. Thyroglobulin, triiodothyronine and thyroxine were present in most of the thyroid disorders, excepting anaplastic and medullary carcinomas. Thyroglobulin and thyroxine were localized both in the follicular epithelium and in the colloid, whereas triiodothyronine was present especially in the follicular cells. The thyroid hormones distribution in benign lesions is rather similar. In carcinomas, the pattern of thyroglobulin, triiodothyronine and thyroxine is more heterogeneous, but generally the triiodothyronine distribution is similar to that of thyroglobulin. In some carcinomas, triiodothyronine and thyroxine showed a weak or negative immunostaining. The immunoperoxidase method is a valuable tool in the study of functional disturbances in the thyroid pathology and in the diagnosis of thyroid carcinoma metastases as well. Positive thyroid hormones staining clearly indicates the thyroid origin of metastases.
作者采用免疫过氧化物酶法研究了58例甲状腺疾病中甲状腺球蛋白、三碘甲状腺原氨酸和甲状腺素的分布模式，这些疾病包括：15例甲状腺功能正常的甲状腺肿、10例格雷夫斯病、7例桥本甲状腺炎、11例滤泡-乳头状癌（6例原发性肿瘤和5例淋巴结转移）、8例滤泡癌、4例未分化癌和3例髓样癌。除未分化癌和髓样癌外，大多数甲状腺疾病中均存在甲状腺球蛋白、三碘甲状腺原氨酸和甲状腺素。甲状腺球蛋白和甲状腺素定位于滤泡上皮和胶质中，而三碘甲状腺原氨酸尤其存在于滤泡细胞中。良性病变中甲状腺激素的分布相当相似。在癌组织中，甲状腺球蛋白、三碘甲状腺原氨酸和甲状腺素的模式更为异质，但一般来说，三碘甲状腺原氨酸的分布与甲状腺球蛋白相似。在一些癌组织中，三碘甲状腺原氨酸和甲状腺素显示出弱阳性或阴性免疫染色。免疫过氧化物酶法是研究甲状腺病理学功能障碍以及诊断甲状腺癌转移的一种有价值的工具。甲状腺激素阳性染色清楚地表明转移灶的甲状腺起源。
