Garcia Yenela, Esquivel Nashelly
Laboratorio de Antianémicos y Nutracéuticos, Centro Nacional de Biopreparados (BioCen), Carretera Beltrán Km 1 ½, Bejucal 32600, Mayabeque, Cuba.
Facultad de Biología, Universidad de la Habana, Plaza de la Revolución 10400, La Habana, Cuba.
Behav Sci (Basel). 2018 Jan 18;8(1):14. doi: 10.3390/bs8010014.
To evaluate several cognitive parameters during the execution of behavioral tasks assessing cognitive function in laboratory animals, the parameters are reported within a range. This situation entails that each laboratory must establish the conditions under which the behavioral task to evaluate the cognitive function can be carried out. C57BL/6 and BALB/c inbred strains are used more often in behavioral studies relating to anxiety, stress, fear and cognitive function. The aim of this work was to compare the behavioral response of mice of the strains BALB/c and C57BL/6 to evaluate memory and learning as cognitive functions. Young male mice, 7-8 weeks of age, from each strain were used. Y maze, object recognition and passive avoidance tasks were performed. Both strains of mice showed differences in the response to the passive avoidance and Y maze task. This study advances knowledge about the baseline behavior of laboratory mice strains and their response during the experimental procedures, which are due to the treatment, genetic influence, procedural differences, genetic background variance, or any combination of these elements.
为了评估在实验室动物执行评估认知功能的行为任务期间的几个认知参数，这些参数是在一个范围内报告的。这种情况意味着每个实验室必须确定能够开展评估认知功能的行为任务的条件。C57BL/6和BALB/c近交系在与焦虑、应激、恐惧和认知功能相关的行为研究中使用得更为频繁。这项工作的目的是比较BALB/c和C57BL/6品系小鼠的行为反应，以评估作为认知功能的记忆和学习能力。使用了来自每个品系的7至8周龄的年轻雄性小鼠。进行了Y迷宫、物体识别和被动回避任务。两个品系的小鼠在被动回避和Y迷宫任务的反应上均表现出差异。本研究推进了关于实验室小鼠品系的基线行为及其在实验程序中的反应的知识，这些反应是由处理、遗传影响、程序差异、遗传背景差异或这些因素的任何组合导致的。
