Antonarakis Emmanuel S
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB1-1M45, Baltimore, MD 21287, USA.
Cancers (Basel). 2018 Jan 18;10(1):22. doi: 10.3390/cancers10010022.
The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This special issue of initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies.
雄激素和雄激素受体（AR）信号传导是前列腺癌发生和疾病进展的标志这一观点已被广泛接受。然而，人们对AR信号传导在其他人类恶性肿瘤中的作用了解较少。本期特刊首先回顾了AR在晚期前列腺癌中的作用，然后探讨了AR信号传导在其他上皮性恶性肿瘤中的潜在重要性。前几篇文章聚焦于新型AR靶向疗法在去势抵抗性前列腺癌中的应用以及对新型抗雄激素药物的耐药机制，同时还概述了AR与其他细胞通路之间的相互作用，包括前列腺癌中的PI3激酶信号传导、转录调控、血管生成、基质因子、Wnt信号传导和表观遗传调控。接下来的几篇文章回顾了雄激素和AR信号传导在乳腺癌、膀胱癌、唾液腺癌和肝细胞癌中的可能作用，以及在这些非前列腺恶性肿瘤中使用抗雄激素疗法的潜在治疗意义。
