Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández, CSIC-UMH, Alicante, Spain.
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Neuron. 2018 Jan 17;97(2):256-258. doi: 10.1016/j.neuron.2018.01.001.
Shh contributes to neural circuit formation with different mechanisms. In this issue, Peng and colleagues (2018) identify a novel trans-axonal mechanism by which Shh derived from contralateral projecting retinal ganglion cells prevents midline crossing of Boc-expressing ipsilateral axons at the optic chiasm.
Shh 通过不同的机制促进神经回路的形成。在本期中，Peng 及其同事（2018）发现了 Shh 的一种新的跨轴机制，即来自对侧投射的视网膜神经节细胞的 Shh 阻止 Boc 表达的同侧轴突在视交叉中线交叉。
