Brain Behavior Laboratory, Neuropsychiatry Division, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania; and the Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pennsylvania.
Brain Behavior Laboratory, Neuropsychiatry Division, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania; and the Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pennsylvania.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Sep;2(6):502-509. doi: 10.1016/j.bpsc.2017.03.010. Epub 2017 Mar 22.
Social cognition impairments in neurodevelopmental disorders impact functioning. Face processing is the most extensively studied aspect of social cognition, commonly indexing this construct in neuropsychiatric disorders compared with typically developing youths. Applying social cognition measures as a Research Domain Criteria concept in the clinical arena requires establishing cutoffs for intervention and identifying vulnerability for psychopathology across disorders. This can be accomplished by comparing extreme performers across multiple clinical symptom features.
The Philadelphia Neurodevelopmental Cohort (N = 9498), a community sample of youths (8-21 years old), was assessed with a structured interview (Kiddie Schedule for Affective Disorders and Schizophrenia). The Penn Computerized Neurocognitive Battery was administered measuring accuracy and response time on Executive, Episodic Memory, Complex Cognition, and Social Cognition domains. We parsed participants by performance on social cognition into tertiles and examined their neurocognitive and clinical profiles.
The top social cognition group outperformed the bottom group in face memory and complex reasoning. Concerning symptoms, the top performing group did not differ from the middle group, but the bottom performing group had higher externalizing and psychosis symptoms. There were sex differences in social cognition and symptom profiles but no sex × performance or sex × diagnosis × domain interactions.
Social cognition is supported by strong face memory and complex reasoning skills. Poor performance portends more severe externalizing and psychosis symptoms. That average performance is sufficient for normative symptomatology suggests that interventions aimed at ameliorating social cognition deficits, as measured here, could be effective in normalizing level of symptoms.
神经发育障碍中的社会认知障碍会影响功能。面部处理是社会认知研究最多的方面，与典型的发展中的年轻人相比，它通常在神经精神障碍中标记这个结构。将社会认知测量应用于临床领域的研究领域标准概念，需要为干预建立截止值，并识别跨障碍的精神病理学易感性。这可以通过比较多个临床症状特征的极端表现者来实现。
费城神经发育队列（N=9498）是一个社区青年样本（8-21 岁），使用结构化访谈（儿童情感障碍和精神分裂症量表）进行评估。宾夕法尼亚计算机神经认知电池用于测量执行、情节记忆、复杂认知和社会认知领域的准确性和反应时间。我们根据社会认知表现将参与者分为三分位，并检查他们的神经认知和临床特征。
在面部记忆和复杂推理方面，表现最好的社会认知组优于表现最差的组。就症状而言，表现最好的组与中间组没有差异，但表现最差的组有更高的外化和精神病症状。社会认知和症状特征存在性别差异，但没有性别×表现或性别×诊断×领域的交互作用。
社会认知得到强大的面部记忆和复杂推理技能的支持。表现不佳预示着更严重的外化和精神病症状。平均表现足以说明正常的症状表明，旨在改善这里测量的社会认知缺陷的干预措施可能会有效地使症状水平正常化。
