Nunes M T, Bianco A C, Migala A, Agostini B, Hasselbach W
Z Naturforsch C Biosci. 1985 Sep-Oct;40(9-10):726-34. doi: 10.1515/znc-1985-9-1025.
The properties of the sarcoplasmic reticulum membranes isolated from slow-twitch type I soleus and fast-twitch type II psoas muscles of control and thyroxine treated rabbits were comparatively studied. Membrane yield, maximal calcium storing capacity, ATP-supported calcium uptake, calcium-dependent ATPase activity and calcium-dependent phosphoprotein formation were found to be 3-10 fold higher in psoas than in soleus preparations. Membrane yield, calcium-dependent ATPase activity, ATP-supported calcium transport and calcium-dependent phosphoprotein are at least twice enhanced in the membranes from soleus muscles of animals treated for 14-21 days with thyroxine. The corresponding capacities of the membranes from psoas muscles are not further augmented by the same thyroxine treatment. The maximal calcium storing capacity of the psoas membranes is their sole specific property which is significantly increased. The changes in the properties of the soleus muscles' sarcoplasmic reticulum membranes are engendered by an increase from 5 to 30-50% in the number of type II fibres. Since the calcium transporting properties of the sarcoplasmic reticulum membranes from type II fibres qualitatively differ from those of type I fibres, thyroxine does not only affect quantitative but also qualitative parameters of the muscles' sarcoplasmic reticulum membrane system.
对取自对照兔和经甲状腺素处理的兔的慢肌Ⅰ型比目鱼肌以及快肌Ⅱ型腰大肌的肌浆网膜特性进行了比较研究。结果发现，腰大肌的膜产量、最大钙储存能力、ATP支持的钙摄取、钙依赖性ATP酶活性以及钙依赖性磷蛋白形成比目鱼肌制剂高3至10倍。用甲状腺素处理14至21天的动物的比目鱼肌膜，其膜产量、钙依赖性ATP酶活性、ATP支持的钙转运和钙依赖性磷蛋白至少提高两倍。相同的甲状腺素处理并未进一步提高腰大肌膜的相应能力。腰大肌膜的最大钙储存能力是其唯一显著增加的特性。比目鱼肌肌浆网膜特性的变化是由Ⅱ型纤维数量从5%增加到30%至50%引起的。由于Ⅱ型纤维的肌浆网膜的钙转运特性在质量上不同于Ⅰ型纤维，甲状腺素不仅影响肌肉肌浆网膜系统的数量参数，还影响其质量参数。
