• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于多重 PCR 的下一代测序和人类与大鼠中汉城病毒的全球多样性。

Multiplex PCR-Based Next-Generation Sequencing and Global Diversity of Seoul Virus in Humans and Rats.

出版信息

Emerg Infect Dis. 2018 Feb;24(2):249-257. doi: 10.3201/eid2402.171216.

DOI:10.3201/eid2402.171216
PMID:29350137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5782898/
Abstract

Seoul virus (SEOV) poses a worldwide public health threat. This virus, which is harbored by Rattus norvegicus and R. rattus rats, is the causative agent of hemorrhagic fever with renal syndrome (HFRS) in humans, which has been reported in Asia, Europe, the Americas, and Africa. Defining SEOV genome sequences plays a critical role in development of preventive and therapeutic strategies against the unique worldwide hantavirus. We applied multiplex PCR-based next-generation sequencing to obtain SEOV genome sequences from clinical and reservoir host specimens. Epidemiologic surveillance of R. norvegicus rats in South Korea during 2000-2016 demonstrated that the serologic prevalence of enzootic SEOV infections was not significant on the basis of sex, weight (age), and season. Viral loads of SEOV in rats showed wide dissemination in tissues and dynamic circulation among populations. Phylogenetic analyses showed the global diversity of SEOV and possible genomic configuration of genetic exchanges.

摘要

首尔病毒（SEOV）对全球公共卫生构成威胁。这种病毒存在于褐家鼠和黑家鼠中，是引起人类肾综合征出血热（HFRS）的病原体，在亚洲、欧洲、美洲和非洲均有报道。定义 SEOV 基因组序列对于开发针对独特的全球汉坦病毒的预防和治疗策略至关重要。我们应用基于多重 PCR 的下一代测序技术从临床和储存宿主标本中获得 SEOV 基因组序列。2000 年至 2016 年期间对韩国褐家鼠的流行病学监测表明，根据性别、体重（年龄）和季节，地方性 SEOV 感染的血清流行率并不显著。SEOV 在大鼠中的病毒载量在组织中广泛传播，并在种群中动态循环。系统发育分析显示了 SEOV 的全球多样性和遗传交换的可能基因组配置。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/5d831e200359/17-1216-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/52c03b5d55e5/17-1216-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/1025b34f40bb/17-1216-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/0995715c2dcb/17-1216-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/5d831e200359/17-1216-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/52c03b5d55e5/17-1216-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/1025b34f40bb/17-1216-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/0995715c2dcb/17-1216-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa62/5782898/5d831e200359/17-1216-F4.jpg

相似文献

1
Multiplex PCR-Based Next-Generation Sequencing and Global Diversity of Seoul Virus in Humans and Rats.基于多重 PCR 的下一代测序和人类与大鼠中汉城病毒的全球多样性。
Emerg Infect Dis. 2018 Feb;24(2):249-257. doi: 10.3201/eid2402.171216.
2
Serological and genetic evidence for the presence of Seoul hantavirus in Rattus norvegicus in Flanders, Belgium.比利时弗拉芒地区褐家鼠中存在汉城汉坦病毒的血清学和遗传学证据。
Scand J Infect Dis. 2009;41(1):51-6. doi: 10.1080/00365540802459994.
3
Multiplex PCR-Based Nanopore Sequencing and Epidemiological Surveillance of in , Republic of Korea.基于多重 PCR 的纳米孔测序与韩国 的流行病学监测
Viruses. 2021 May 6;13(5):847. doi: 10.3390/v13050847.
4
A Development of Rapid Whole-Genome Sequencing of Using a Portable One-Step Amplicon-Based High Accuracy Nanopore System.利用便携式一步法基于扩增子的高通量纳米孔测序系统进行快速全基因组测序的开发。
Viruses. 2023 Jul 13;15(7):1542. doi: 10.3390/v15071542.
5
Phylogenetic analysis based on mitochondrial DNA sequences of wild rats, and the relationship with Seoul virus infection in Hubei, China.基于野生大鼠线粒体DNA序列的系统发育分析及其与中国湖北汉城病毒感染的关系。
Virol Sin. 2017 Jun;32(3):235-244. doi: 10.1007/s12250-016-3940-0. Epub 2017 Jun 26.
6
Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe.从荷兰的大鼠（Rattus norvegicus）中分离出的汉城病毒基因组的遗传分析揭示了其进入欧洲的多种传播途径。
J Med Virol. 2019 May;91(5):724-730. doi: 10.1002/jmv.25390. Epub 2019 Jan 15.
7
Human infection with Seoul orthohantavirus in Korea, 2019.韩国 2019 年首尔型正汉坦病毒人体感染病例
PLoS Negl Trop Dis. 2021 Feb 22;15(2):e0009168. doi: 10.1371/journal.pntd.0009168. eCollection 2021 Feb.
8
Genetic characterization of seoul hantavirus originated from norway rats (Rattus norvegicus) captured in Belgium.源自于比利时捕获的挪威褐家鼠（Rattus norvegicus）的汉城型汉坦病毒的遗传特征。
J Med Virol. 2012 Aug;84(8):1298-303. doi: 10.1002/jmv.23321.
9
Urban Rodent Surveillance, Climatic Association, and Genomic Characterization of Seoul Virus Collected at U.S. Army Garrison, Seoul, Republic of Korea, 2006-2010.2006-2010 年在韩国首尔美军基地进行的城市啮齿动物监测、气候关联和首尔病毒的基因组特征分析。
Am J Trop Med Hyg. 2018 Aug;99(2):470-476. doi: 10.4269/ajtmh.17-0459. Epub 2018 May 31.
10
Role of Seaports and Imported Rats in Seoul Hantavirus Circulation, Africa.非洲塞港口和进口鼠在首尔汉坦病毒传播中的作用。
Emerg Infect Dis. 2023 Jan;29(1):20-25. doi: 10.3201/eid2901.221092.

引用本文的文献

1
Longitudinal study of Orthohantavirus hantanense in Apodemus agrarius and disease risk assessment in the Republic of Korea during 2000-2019.2000 - 2019年韩国黑线姬鼠中汉坦病毒的纵向研究及疾病风险评估
Sci Rep. 2025 Aug 22;15(1):30872. doi: 10.1038/s41598-025-16897-3.
2
Discovery and genomic characterization of Ulleung virus harbored by Crocidura utsuryoensis on Ulleung Island in Republic of Korea.韩国郁陵岛短尾鼩携带的郁陵病毒的发现及基因组特征分析
Sci Rep. 2025 Jul 1;15(1):21748. doi: 10.1038/s41598-025-06845-6.
3
Distribution and Genetic Characteristics of Seoul Virus in Different Organs of .

本文引用的文献

1
Notes from the Field: Multiple Cases of Seoul Virus Infection in a Household with Infected Pet Rats - Tennessee, December 2016-April 2017.实地记录：2016年12月至2017年4月田纳西州一户家庭中宠物鼠感染汉城病毒的多起病例
MMWR Morb Mortal Wkly Rep. 2017 Oct 13;66(40):1081-1082. doi: 10.15585/mmwr.mm6640a4.
2
Seoul Virus Infection in Humans, France, 2014-2016.2014-2016 年法国人类感染汉城病毒。
Emerg Infect Dis. 2017 Jun;23(6):973-977. doi: 10.3201/eid2306.160927. Epub 2017 Jun 15.
3
Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea.
汉坦病毒在……不同器官中的分布及遗传特征 。 你提供的原文似乎不完整，“Distribution and Genetic Characteristics of Seoul Virus in Different Organs of.”后面缺少具体的研究对象等关键信息。
Viruses. 2025 Mar 14;17(3):412. doi: 10.3390/v17030412.
4
Detection and genomic characterization of foot and mouth disease virus SAT2 XIV topotype using amplicon-based nanopore sequencing.使用基于扩增子的纳米孔测序技术对口蹄疫病毒SAT2 XIV 拓扑型进行检测和基因组特征分析。
Vet Res Commun. 2025 Mar 19;49(3):144. doi: 10.1007/s11259-025-10718-8.
5
A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs.一种人类致病性汉坦病毒在分类学上多样的啮齿动物宿主中传播并排出。
PLoS Pathog. 2025 Jan 21;21(1):e1012849. doi: 10.1371/journal.ppat.1012849. eCollection 2025 Jan.
6
An amplicon-based nanopore sequencing workflow for rapid tracking of avian influenza outbreaks, France, 2020-2022.一种基于扩增子的纳米孔测序工作流程，用于快速追踪2020 - 2022年法国禽流感疫情。
Front Cell Infect Microbiol. 2024 Jan 22;14:1257586. doi: 10.3389/fcimb.2024.1257586. eCollection 2024.
7
A Development of Rapid Whole-Genome Sequencing of Using a Portable One-Step Amplicon-Based High Accuracy Nanopore System.利用便携式一步法基于扩增子的高通量纳米孔测序系统进行快速全基因组测序的开发。
Viruses. 2023 Jul 13;15(7):1542. doi: 10.3390/v15071542.
8
A Portable Diagnostic Assay, Genetic Diversity, and Isolation of Seoul Virus from Collected in Gangwon Province, Republic of Korea.从大韩民国江原道采集的汉坦病毒的便携式诊断检测、遗传多样性及分离
Pathogens. 2022 Sep 14;11(9):1047. doi: 10.3390/pathogens11091047.
9
Genotyping and Molecular Diagnosis of Hepatitis A Virus in Human Clinical Samples Using Multiplex PCR-Based Next-Generation Sequencing.使用基于多重PCR的下一代测序技术对人类临床样本中的甲型肝炎病毒进行基因分型和分子诊断。
Microorganisms. 2022 Jan 4;10(1):100. doi: 10.3390/microorganisms10010100.
10
Detection and Genetic Characterization of Seoul Virus in Liver Tissue Samples From and in Urban Areas of Southern China.中国南方城市地区[具体地点1]和[具体地点2]肝脏组织样本中汉城病毒的检测及基因特征分析
Front Vet Sci. 2021 Dec 13;8:748232. doi: 10.3389/fvets.2021.748232. eCollection 2021.
韩国鼩鼱携带的汉坦病毒（Imjin 病毒）的动态循环和遗传交换。
Sci Rep. 2017 Mar 15;7:44369. doi: 10.1038/srep44369.
4
Complete mapping of viral escape from neutralizing antibodies.病毒对中和抗体逃逸的完整图谱
PLoS Pathog. 2017 Mar 13;13(3):e1006271. doi: 10.1371/journal.ppat.1006271. eCollection 2017 Mar.
5
Clinical and biological insights from viral genome sequencing.病毒基因组测序的临床与生物学见解。
Nat Rev Microbiol. 2017 Mar;15(3):183-192. doi: 10.1038/nrmicro.2016.182. Epub 2017 Jan 16.
6
Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform.通过一个完全集成的基于网络的生物信息学平台，推动基因组学革命的民主化。
Nucleic Acids Res. 2017 Jan 9;45(1):67-80. doi: 10.1093/nar/gkw1027. Epub 2016 Nov 28.
7
Genetic Diversity and Reassortment of Hantaan Virus Tripartite RNA Genomes in Nature, the Republic of Korea.韩国汉坦病毒三方RNA基因组的遗传多样性与重配现象
PLoS Negl Trop Dis. 2016 Jun 17;10(6):e0004650. doi: 10.1371/journal.pntd.0004650. eCollection 2016 Jun.
8
Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing.基于多重PCR的下一代测序技术对肾综合征出血热患者进行系统发育地理学分析。
Sci Rep. 2016 May 25;6:26017. doi: 10.1038/srep26017.
9
Reassortment in segmented RNA viruses: mechanisms and outcomes.分段RNA病毒中的重配：机制与结果
Nat Rev Microbiol. 2016 Jul;14(7):448-60. doi: 10.1038/nrmicro.2016.46. Epub 2016 May 23.
10
Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in an area of high endemicity in Republic of Korea.在韩国高流行区抗汉坦病毒IgG血清阴性啮齿动物中检测汉坦病毒RNA
Microbiol Immunol. 2016 Apr;60(4):268-71. doi: 10.1111/1348-0421.12370.