Department of Cognitive Neurology, Sunnybrook Health Sciences Centre.
Department of Psychiatry and Ophthalmology, University Health Network, University of Toronto, Toronto, ON, Canada.
Alzheimer Dis Assoc Disord. 2018 Apr-Jun;32(2):162-171. doi: 10.1097/WAD.0000000000000243.
The purpose of this review is to provide an overview of the research regarding circadian rhythms in Alzheimer disease (AD). Furthermore, this paper explores the role of melatonin in the pathogenesis of AD and the limitation of trials addressing circadian rhythms disturbances in the AD population. A literature search using Medline with PubMed and Embase was carried out identifying papers focusing on circadian rhythms in AD. Sleep disorders and especially circadian rhythm disturbances are very common in the elderly population but definitely more pronounced in patients with AD. The lack of trials evaluating the management of circadian rhythms disorders in the elderly population and especially in AD should be considered of the utmost importance. Although there is a better understanding about the pathophysiology of AD and its relationship with circadian disorders, further studies in human models need to be conducted.
本次综述旨在概述有关阿尔茨海默病（AD）中昼夜节律的研究。此外，本文还探讨了褪黑素在 AD 发病机制中的作用，以及针对 AD 人群中昼夜节律紊乱进行试验的局限性。通过使用 Medline 联合 PubMed 和 Embase 进行文献检索，确定了关注 AD 中昼夜节律的论文。睡眠障碍，尤其是昼夜节律紊乱，在老年人群中非常常见，但在 AD 患者中更为明显。在评估老年人群，尤其是 AD 患者中昼夜节律紊乱的管理方面，缺乏试验应该被认为是极其重要的。尽管人们对 AD 的病理生理学及其与昼夜节律紊乱的关系有了更好的理解，但仍需要在人类模型中进行进一步的研究。
