Royer H D, Campen T J, Ramarli D, Chang H C, Acuto O, Reinherz E L
Behring Inst Mitt. 1985 Aug(77):1-21.
Recent studies using cloned antigen specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90 KD Ti heterodimer and the in-variant 20 and 25 KD T3 molecules. Approximately 30,000-40,000 Ti and T3 molecules exist on the surface of human T lymphocytes. These glycoproteins are acquired and expressed during late thymic ontogeny, thus providing the structural basis for immunologic competence. The alpha and beta subunits of Ti bear no precursor-product relationship to one another and are encoded by separate germline V, D, J and C segments which rearrange during intrathymic differentiation to form an active gene set. Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous IL-2 production, release, and subsequent binding to IL-2 receptors. The implications of these findings for understanding of human T cell growth and its regulation in disease states are discussed.
最近利用克隆的抗原特异性T淋巴细胞以及针对其各种表面糖蛋白成分的单克隆抗体进行的研究，已导致将人类T细胞抗原受体鉴定为一种表面复合物，该复合物由一个克隆型90KD的Ti异二聚体和不变的20KD及25KD的T3分子组成。人类T淋巴细胞表面存在约30,000 - 40,000个Ti和T3分子。这些糖蛋白在胸腺发育后期获得并表达，从而为免疫能力提供结构基础。Ti的α和β亚基彼此之间不存在前体 - 产物关系，并且由单独的种系V、D、J和C区段编码，这些区段在胸腺内分化过程中重排以形成一个活性基因集。T3 - Ti受体复合物的触发会导致游离细胞质Ca2+迅速增加，并通过涉及内源性IL - 2产生、释放以及随后与IL - 2受体结合的自分泌途径引发特异性抗原诱导的增殖。本文讨论了这些发现对于理解人类T细胞生长及其在疾病状态下的调节的意义。
