Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryl.
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryl.
J Infect Dis. 2018 Mar 13;217(7):1153-1159. doi: 10.1093/infdis/jiy024.
Antimicrobial peptides (AMPs) constitute an important part of innate host defense. Possibly limiting the therapeutic potential of AMPs is the fact that bacteria have developed AMP resistance mechanisms during their co-evolution with humans. However, there is no direct evidence that AMP resistance per se is important during an infection. Here we show that the Staphylococcus aureus Pmt ABC transporter defends the bacteria from killing by important human AMPs and elimination by human neutrophils. By showing that Pmt contributes to virulence during skin infection in an AMP-dependent manner, we provide evidence that AMP resistance plays a key role in bacterial infection.
抗菌肽 (AMPs) 是先天宿主防御的重要组成部分。可能限制 AMP 治疗潜力的事实是，细菌在与人类共同进化的过程中已经发展出 AMP 耐药机制。然而，目前没有直接证据表明 AMP 耐药本身在感染过程中很重要。在这里，我们表明金黄色葡萄球菌 Pmt ABC 转运蛋白可防止细菌被重要的人类 AMP 杀死并被人类中性粒细胞清除。通过表明 Pmt 以 AMP 依赖的方式有助于皮肤感染中的毒力，我们提供了 AMP 耐药在细菌感染中起关键作用的证据。
