Kinet J P, Quarto R, Perez-Montfort R, Metzger H
Biochemistry. 1985 Dec 3;24(25):7342-8. doi: 10.1021/bi00346a048.
We describe experiments which indicate that lipids interact with the receptor for immunoglobulin E (IgE) in several ways. Evidence for loosely bound lipid comes from observations on the special conditions that are required in order to oxidatively iodinate the alpha chain of the receptor in IgE-receptor complexes. Evidence for tightly, but still noncovalently, bound lipids comes from studies on the lipids required to inhibit dissociation of the subunits of the receptor in micellar detergent. Finally, biosynthetic studies indicate that the subunits of the receptor contain ester-linked fatty acids. The latter modification appears to take place on receptors that have already been inserted into the plasma membrane.
我们描述了一些实验，这些实验表明脂质以多种方式与免疫球蛋白E（IgE）受体相互作用。关于松散结合脂质的证据来自对IgE-受体复合物中受体α链进行氧化碘化所需特殊条件的观察。关于紧密但仍为非共价结合脂质的证据来自对抑制胶束洗涤剂中受体亚基解离所需脂质的研究。最后，生物合成研究表明受体亚基含有酯连接的脂肪酸。后一种修饰似乎发生在已经插入质膜的受体上。
