一种用于预测整合膜蛋白中螺旋结构的构象偏好参数。
A conformational preference parameter to predict helices in integral membrane proteins.
作者信息
Mohana Rao J K, Argos P
出版信息
Biochim Biophys Acta. 1986 Jan 30;869(2):197-214. doi: 10.1016/0167-4838(86)90295-5.
Assignments were made for helical regions in several integral membrane proteins using an algorithm devised to delineate the transmembrane helices in bacteriorhodopsin (Eur. J. Biochem. 182 (1982) 565-575). A new conformational preference parameter for membrane-buried helices was obtained. The use of this parameter to predict helices in membrane proteins is discussed. When applied to the L and M subunits of Rhodopseudomonas sphaeroides, five helices were predicted, which is consistent with the three-dimensional X-ray crystal structure. Data on signal sequences and amino acid exchanges in membrane proteins are also analysed and discussed
使用一种设计用于描绘细菌视紫红质跨膜螺旋的算法（《欧洲生物化学杂志》182卷（1982年）565 - 575页），对几种整合膜蛋白中的螺旋区域进行了划分。获得了一种用于膜埋螺旋的新的构象偏好参数。讨论了使用该参数预测膜蛋白中螺旋的情况。当应用于球形红假单胞菌的L和M亚基时，预测出五个螺旋，这与三维X射线晶体结构一致。还对膜蛋白中信号序列和氨基酸交换的数据进行了分析和讨论。
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