Partial tandem duplication of may predict a subset of myelodysplastic syndrome with unique characteristics and poor outcome.
作者信息
Choi Sarah M, Dewar Rajan, Burke Patrick W, Shao Lina
机构信息
Department of Pathology, University of Michigan, Ann Arbor, MI, USA
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
出版信息
Haematologica. 2018 Mar;103(3):e131-e134. doi: 10.3324/haematol.2017.185249. Epub 2018 Jan 19.
Abstract
摘要
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Partial tandem duplication of may predict a subset of myelodysplastic syndrome with unique characteristics and poor outcome.[基因名称]的部分串联重复可能预示着具有独特特征和不良预后的骨髓增生异常综合征的一个亚组。
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Mutation analysis for RUNX1, MLL-PTD, FLT3-ITD, NPM1 and NRAS in 269 patients with MDS or secondary AML.对269例骨髓增生异常综合征（MDS）或继发性急性髓系白血病（AML）患者进行RUNX1、MLL-PTD、FLT3-ITD、NPM1和NRAS的突变分析。
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The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy.MLL部分串联重复：急性髓系白血病中隐性功能获得的证据确定了分子靶向治疗的一个新患者亚组。
Blood. 2005 Jul 1;106(1):345-52. doi: 10.1182/blood-2005-01-0204. Epub 2005 Mar 17.
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Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia.956例成年急性髓系白血病患者中MLL部分串联重复和FLT3内部串联重复突变的比较分析
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Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.MLL基因部分串联重复在16至60岁急性髓系白血病且细胞遗传学正常的成年患者中的预后意义：乌尔姆急性髓系白血病研究组的一项研究
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Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23.急性髓系白血病中MLL基因部分串联重复在11q23无染色体异常时的临床及生物学意义
Leukemia. 2002 Feb;16(2):196-202. doi: 10.1038/sj.leu.2402352.
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