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采用毛细管气相色谱-质量选择检测法同时测定人血液中的卡托普利和S-苯甲酰卡托普利。

Simultaneous determination of captopril and S-benzoyl captopril in human blood by capillary gas chromatography-mass selective detection.

作者信息

Jemal M, Ivashkiv E, Cohen A I

出版信息

Biomed Mass Spectrom. 1985 Nov;12(11):664-7. doi: 10.1002/bms.1200121107.

DOI:10.1002/bms.1200121107
PMID:2935201
Abstract

Using a new table-top electron-impact mass selective detector, interfaced with a narrow bore, fused silica capillary gas chromatograph, a method has been developed for the simultaneous determination of captopril and S-benzoyl captopril. With a capillary column the two components could be chromatographically resolved, thus permitting the use of electron-impact ionization for quantitative measurements.

摘要

使用一种新型台式电子轰击质量选择性检测器,并与窄孔熔融石英毛细管气相色谱仪联用,已开发出一种同时测定卡托普利和S-苯甲酰卡托普利的方法。使用毛细管柱时,这两种成分能够在色谱上分离,从而可以采用电子轰击电离进行定量测定。

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1
Simultaneous determination of captopril and S-benzoyl captopril in human blood by capillary gas chromatography-mass selective detection.采用毛细管气相色谱-质量选择检测法同时测定人血液中的卡托普利和S-苯甲酰卡托普利。
Biomed Mass Spectrom. 1985 Nov;12(11):664-7. doi: 10.1002/bms.1200121107.
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Simultaneous determination of the prodrug zofenopril and its active drug in plasma by capillary gas chromatography-mass-selective detection.通过毛细管气相色谱-质量选择性检测同时测定血浆中的前体药物佐芬普利及其活性药物。
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Determination of S-benzoyl captopril in human urine by capillary gas chromatography with electron-capture detection.
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Identification and determination of the S-methyl metabolite of captopril in human plasma by selected-ion monitoring gas chromatography-mass spectrometry.采用选择离子监测气相色谱-质谱法鉴定和测定人血浆中卡托普利的S-甲基代谢物。
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Sensitive method for determination of captopril in biological fluids by gas chromatography-mass spectrometry.气相色谱-质谱联用法定量生物样品中卡托普利的灵敏方法。
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Spectrofluorometric determination of captopril plus captopril disulfide metabolites in plasma.血浆中卡托普利及其二硫化物代谢产物的荧光分光光度法测定
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Determination of captopril in human blood by gas chromatography-negative-ion chemical ionization mass spectrometry with [18O4]captopril as internal standard.以[¹⁸O₄]卡托普利为内标,采用气相色谱-负离子化学电离质谱法测定人血中的卡托普利。
J Chromatogr. 1990 Aug 3;529(2):299-308. doi: 10.1016/s0378-4347(00)83836-0.
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Determination of captopril in biological fluids by gas-liquid chromatography.气液色谱法测定生物流体中的卡托普利。
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Determination of total captopril in human plasma by gas chromatography-mass spectrometry with selected-ion monitoring after reduction of disulfides.在二硫化物还原后,采用气相色谱-质谱联用仪选择离子监测法测定人血浆中卡托普利的总量。
J Pharm Sci. 1984 Aug;73(8):1113-7. doi: 10.1002/jps.2600730822.

引用本文的文献

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Captopril. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure.卡托普利。其药效学和药代动力学特性的最新进展,以及在高血压和充血性心力衰竭中的治疗应用。
Drugs. 1988 Nov;36(5):540-600. doi: 10.2165/00003495-198836050-00003.