Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Sci Rep. 2018 Jan 19;8(1):1175. doi: 10.1038/s41598-018-19243-y.
The ankle-brachial index (ABI) is a reliable diagnostic examination for peripheral arterial occlusive disease (PAOD). We previously reported CHADS score was significantly correlated with PAOD. However, the association between CHADS-VASc score and ABI < 0.9 is not evaluated in the literature. The aim of the present study was to investigate whether CHADS-VASc score has a strong association with PAOD. We enrolled 1482 patients in this study. PAOD was defined as ABI < 0.9 in either leg. Vascular disease in CHADS-VASc score was modified as vascular disease except PAOD. Of the 1482 subjects, the prevalence of ABI < 0.9 was 5.6%. Multivariate analysis showed that the increased age, decreased estimated glomerular filtration rate and increased modified CHADS-VASc score (OR, 1.764; p < 0.001) were independent associated with ABI < 0.9. In addition, the percentage of ABI < 0.9 in patients with modified CHADS-VASc score of 0, 1, and <2 were 0%, 0.9%, and 0.7%, respectively (All < 1%). Our study demonstrated modified CHADS-VASc score was significantly associated with ABI < 0.9. Calculation of modified CHADS-VASc score might be useful in identifying patients with PAOD and in stratifying the risk of PAOD in non-AF patients.
踝臂指数（ABI）是一种可靠的外周动脉闭塞性疾病（PAOD）诊断检查。我们之前报告过 CHADS 评分与 PAOD 显著相关。然而，CHADS-VASc 评分与 ABI<0.9 之间的关联在文献中尚未得到评估。本研究的目的是探讨 CHADS-VASc 评分与 PAOD 是否具有强相关性。我们共纳入了 1482 例患者。PAOD 的定义为双下肢 ABI<0.9。CHADS-VASc 评分中的血管疾病被修改为除 PAOD 以外的血管疾病。在 1482 例患者中，ABI<0.9 的患病率为 5.6%。多变量分析显示，年龄增加、估算肾小球滤过率降低和改良 CHADS-VASc 评分升高（OR，1.764；p<0.001）与 ABI<0.9 独立相关。此外，改良 CHADS-VASc 评分为 0、1 和<2 的患者中 ABI<0.9 的比例分别为 0%、0.9%和 0.7%（均<1%）。我们的研究表明，改良 CHADS-VASc 评分与 ABI<0.9 显著相关。计算改良 CHADS-VASc 评分可能有助于识别 PAOD 患者，并对非房颤患者的 PAOD 风险进行分层。
