Prostran M, Varagić V M
C R Seances Soc Biol Fil. 1985;179(3):316-9.
Forskolin (0.16-1.3 mumol l-1 produced a concentration-dependent increase in both the isometric contraction and the atrial rate. The effects developed slowly, 5 to 8 minutes after the drug was added into the organ bath. Forskolin produced positive inotropic and chronotropic effects also in the presence of isoprenaline. The effects of forskolin were significantly inhibited in the presence of increased concentrations of verapamil in the organ bath. These results indicate that the action of forskolin is mediated by stimulation of the adenylate cyclase system, but in some steps of this action, calcium is also implicated.
福司可林（0.16 - 1.3 μmol l-1）使等长收缩和心房率呈浓度依赖性增加。效应出现缓慢，在药物加入器官浴后5至8分钟出现。福司可林在异丙肾上腺素存在时也产生正性肌力和变时性效应。在器官浴中维拉帕米浓度增加时，福司可林的效应被显著抑制。这些结果表明，福司可林的作用是通过刺激腺苷酸环化酶系统介导的，但在这一作用的某些步骤中，钙也参与其中。
