Ahmad Shah Adil Ishtiyaq, Anam Mohammad Badrul, Ito Naofumi, Ohta Kunimasa
Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Stem Cell-Based Tissue Regeneration Research and Education Unit, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
J Cell Commun Signal. 2018 Mar;12(1):205-210. doi: 10.1007/s12079-018-0452-8. Epub 2018 Jan 19.
Tsukushi (TSK) is a small signaling molecule which takes part in different developmental processes of multiple vertebrate organisms. The diverse activity of TSK depends on its ability to bind various intermediate molecules from different major signaling pathways. Interactions of TSK with BMP, FGF, TGF-β and Wnt pathways have already been confirmed. In this review, we will introduce the latest information regarding the involvement of TSK in developmental events. We suggest a fine tuning role for TSK in multiple signaling cascades. Also, we recommend further studies on the developmental role of TSK to fully reveal its potential.
筑丝蛋白(TSK)是一种小信号分子,参与多种脊椎动物机体的不同发育过程。TSK的多样活性取决于其与来自不同主要信号通路的各种中间分子结合的能力。TSK与骨形态发生蛋白(BMP)、成纤维细胞生长因子(FGF)、转化生长因子-β(TGF-β)和Wnt信号通路的相互作用已得到证实。在本综述中,我们将介绍有关TSK参与发育事件的最新信息。我们认为TSK在多个信号级联反应中起微调作用。此外,我们建议进一步研究TSK的发育作用,以充分揭示其潜力。