富含亮氨酸的小分子重复序列蛋白聚糖中的序列特征、结构、配体相互作用及疾病
Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans.
作者信息
Matsushima Norio, Miyashita Hiroki, Kretsinger Robert H
机构信息
Division of Bioinformatics, Institute of Tandem Repeats, Noboribetsu, 059-0464, Japan.
Center for Medical Education, Sapporo Medical University, Sapporo, 060-8556, Japan.
出版信息
J Cell Commun Signal. 2021 Dec;15(4):519-531. doi: 10.1007/s12079-021-00616-4. Epub 2021 Apr 15.
Abstract
Small leucine rich repeat proteoglycans (SLRPs) are a group of active components of the extracellular matrix in all tissues. SLRPs bind to collagens and regulate collagen fibril growth and fibril organization. SLRPs also interact with various cytokines and extracellular compounds, which lead to various biological functions such cell adhesion and signaling, proliferation, and differentiation. Mutations in SLRP genes are associated with human diseases. Now crystal structures of five SLRPs are available. We describe some features of amino acid sequence and structures of SLRPs. We also review ligand interactions and then discuss the interaction surfaces. Furthermore, we map mutations associated with human diseases and discuss possible effects on structures by the mutations.
摘要
富含亮氨酸的小分子重复蛋白聚糖（SLRPs）是所有组织细胞外基质的一组活性成分。SLRPs与胶原蛋白结合并调节胶原纤维的生长和纤维组织。SLRPs还与多种细胞因子和细胞外化合物相互作用，从而导致各种生物学功能，如细胞粘附和信号传导、增殖和分化。SLRP基因突变与人类疾病有关。目前已有5种SLRPs的晶体结构。我们描述了SLRPs氨基酸序列和结构的一些特征。我们还综述了配体相互作用，然后讨论了相互作用表面。此外，我们绘制了与人类疾病相关的突变图谱，并讨论了这些突变对结构可能产生的影响。
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