Diversity oriented synthesis of chromene-xanthene hybrids as anti-breast cancer agents.
作者信息
Srinivas Lavanya Kumar M, Singh Jyotsana, Manna Sudipta Kumar, Maji Saroj, Konwar Rituraj, Panda Gautam
机构信息
CSIR-Central Drug Research Institute, BS 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
Endocrinology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India.
出版信息
Bioorg Med Chem Lett. 2018 Feb 15;28(4):778-782. doi: 10.1016/j.bmcl.2017.12.065. Epub 2018 Jan 6.
A diverse library of chromene-xanthene hybrids were synthesized through intramolecular Friedel-Crafts reaction of the arenoxy carbinols. Examples include first incorporation of amino acid tyrosine into xanthene skeletons with polar functionalities. A careful structural evaluation revealed that tyrosine crafted chromene-xanthene hybrids exhibited good activities against breast cancer cell lines MCF-7, MDA-MB-231. The lead compound 16 displays significant cell cycle arrest at G1 phase and induces apoptosis in MDA-MB-231 cells.
Zotero 插件