Jobs Katarzyna, Jung Anna, Lewicki Sławomir, Murawski Piotr, Pączek Leszek, Zdanowski Robert
Military Institute of Medicine, Clinic of Paediatrics, Nephrology and Paediatric Allergology, Warsaw, Poland.
Military Institute of Hygiene and Epidemiology, Department of Regenerative Medicine and Cell Biology, Warsaw, Poland.
Urol J. 2018 Sep 26;15(5):231-237. doi: 10.22037/uj.v0i0.3956.
The aim of the study was assessment of four selected macromolecules level: osteopontin, calgranulin, uromodulin and bikunin in fresh morning urine sample in children with nephrolithiasis in the course of idiopathic hypercalciuria.
The study included 90 subjects aged from 12 months to 18 years. The study group comprised 57 subjects- children with urinary tract lithiasis in the course of idiopathic hypercalciuria and the control group - 33 healthy children with no history of urolithiasis. Determinations of osteopontin, calgranulin, uromodulin and bikunin levels in the first morning urine were performed.
The study group had a significantly decreased osteopontin excretion and significantly increased bikuninexcretion, and increased, however statistically nonsignificant, calgranulin excretion in comparison with the control group. Uromodulin excretion did not differ between groups. In both groups a statistically significant positive correlation was observed between uromodulin and bikunin levels.
Children with urinary tract lithiasis in the course of idiopathic hypercalciuria reveal a different distribution of the study proteins than a healthy population.
本研究旨在评估特发性高钙尿症患儿肾结石病程中晨尿样本中四种选定大分子物质的水平：骨桥蛋白、钙粒蛋白、尿调节蛋白和比基尼蛋白。
该研究纳入了90名年龄在12个月至18岁之间的受试者。研究组包括57名患有特发性高钙尿症并伴有尿路结石的儿童，对照组为33名无尿路结石病史的健康儿童。对晨尿中骨桥蛋白、钙粒蛋白、尿调节蛋白和比基尼蛋白水平进行了测定。
与对照组相比，研究组骨桥蛋白排泄量显著降低，比基尼蛋白排泄量显著增加，钙粒蛋白排泄量增加，但无统计学意义。两组间尿调节蛋白排泄量无差异。两组中尿调节蛋白和比基尼蛋白水平之间均观察到具有统计学意义的正相关。
特发性高钙尿症患儿伴有尿路结石时，与健康人群相比，所研究蛋白质分布不同。
