Department of Epidemiology, School of Public Health, Arak University of Medical Sciences, Arak, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Knowledge Utilization Research Center, Tehran University of Medical Science, Tehran, Iran.
Mult Scler Relat Disord. 2018 Feb;20:100-103. doi: 10.1016/j.msard.2018.01.008. Epub 2018 Jan 31.
The epidemiology of multiple sclerosis (MS) includes a consideration of geography and population ethnicity. To determine whether there is any association between ethnicity and risk of MS in a multiethnic, population-based case-control study.
We conducted a population-based case-control of 547 incident MS cases and 1057 healthy controls between August 2013 and February 2015, Tehran, a multi-ethnic city. The patients were identified and enrolled through the Iranian MS Society. Case status was confirmed by a panel of MS specialists beside of 2010 McDonald criteria. Controls were selected through random digit dialing. A logistic regression model was applied to estimate the odds ratios (95%CI) adjusted for age, sex, tobacco smoking and socioeconomic status.
The risk of MS for Kurd, Turk and Fars ethnicities was apparently smaller compared to one specific ethnic background (Lor); OR 0.36 (0.15-0.86) for Kurd, OR 0.42 (0.24-0.74) for Turk and OR 0.53 (0.31-0.89) for Fars. Heterogeneity in parental ethnicity of common ethnic groups was significantly associated with increased risk of MS OR 1.61 (1.13-2.29). All associations remained after adjustment for relevant confounders.
MS was unequally distributed in the ethnic groups. Moreover, heterogeneity in parental ethnicity seems to be a risk factor for MS.
多发性硬化症（MS）的流行病学包括对地理位置和人口种族的考虑。为了在一项多民族、基于人群的病例对照研究中确定种族与 MS 风险之间是否存在任何关联。
我们在 2013 年 8 月至 2015 年 2 月期间在多民族城市德黑兰进行了一项基于人群的 547 例新发性 MS 病例和 1057 名健康对照的病例对照研究。通过伊朗多发性硬化症协会确定并招募了患者。病例状况通过一组 MS 专家与 2010 年麦当劳标准相结合来确认。对照是通过随机数字拨号选择的。应用逻辑回归模型来估计调整年龄、性别、吸烟和社会经济地位后的优势比（95%CI）。
与特定种族背景（Lor）相比，库尔德人、土库曼人和法尔斯人的 MS 风险明显较小；库尔德人 OR 0.36（0.15-0.86），土库曼人 OR 0.42（0.24-0.74），法尔斯人 OR 0.53（0.31-0.89）。常见种族的父母种族异质性与 MS 风险增加显著相关，OR 1.61（1.13-2.29）。在调整相关混杂因素后，所有关联仍然存在。
MS 在不同种族群体中的分布不均。此外，父母种族的异质性似乎是 MS 的一个危险因素。
