Martín-Martín Natalia, Carracedo Arkaitz, Torrano Verónica
CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.
Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain.
Front Cell Dev Biol. 2018 Jan 5;5:119. doi: 10.3389/fcell.2017.00119. eCollection 2017.
Cellular plasticity, or the ability of a cancer cell to adapt to changes in the microenvironment, is a major determinant of cell survival and functionality that require the coordination of transcriptional programs with signaling and metabolic pathways. In this scenario, these pathways sense and integrate nutrient signals for the induction of coordinated gene expression programs in cancer. This minireview focuses on recent advances that shed light on the bidirectional relationship between metabolism and gene transcription, and their biological outcomes in cancer. Specifically, we will discuss how metabolic changes occurring in cancer cells impact on gene expression, both at the level of the epigenetic landscape and transcription factor regulation.
细胞可塑性，即癌细胞适应微环境变化的能力，是细胞存活和功能的主要决定因素，这需要转录程序与信号传导和代谢途径的协调。在这种情况下，这些途径感知并整合营养信号，以诱导癌症中协调的基因表达程序。本综述聚焦于近期的进展，这些进展揭示了代谢与基因转录之间的双向关系及其在癌症中的生物学结果。具体而言，我们将讨论癌细胞中发生的代谢变化如何在表观遗传格局和转录因子调控水平上影响基因表达。
