Schueler R O, White G, Schueler R L, Steiner J M, Wassef A
Veterinary Neurology and Rehabilitation Center, Westminster, Maryland, 21158, USA.
Fresno Veterinary Specialty and Emergency Center, Fresno, California, 93710, USA.
J Small Anim Pract. 2018 May;59(5):305-310. doi: 10.1111/jsap.12818. Epub 2018 Jan 22.
To determine the differences in serum canine pancreatic lipase immunoreactivity between dogs with intervertebral disc herniation and healthy control dogs.
Eighty-four client-owned dogs with intervertebral disc herniation, diagnosed by neurologic examination and imaging, and 18 healthy control dogs. Samples of whole blood were collected within 90 minutes of admission. Serum canine pancreatic lipase immunoreactivity concentrations were measured by a commercial immunoassay and evaluated for association with intervertebral disc herniation, signalment, neurolocalisation and the preadmission administration of glucocorticosteriods or non-steroidal anti-inflammatory drugs.
Serum canine pancreatic lipase immunoreactivity concentrations were statistically increased in dogs with intervertebral disc herniation (P<0·01, n=38). A subgroup of dogs (19/38) with elevated canine pancreatic lipase immunoreactivity concentrations was re-evaluated between 2 and 4 weeks later, and 15 had resolution of clinical signs and values less than 200 μg/L. Serum canine pancreatic lipase immunoreactivity concentrations were not significantly correlated with clinical gastrointestinal disease, neurolocalisation or the preadmission administration of corticosteroids or non-steroidal anti-inflammatory drugs.
These results suggest that serum canine pancreatic lipase immunoreactivity concentrations are significantly elevated in dogs with intervertebral disc herniation.
确定椎间盘突出症犬与健康对照犬血清犬胰脂肪酶免疫反应性的差异。
84只经神经学检查和影像学诊断为椎间盘突出症的客户自养犬，以及18只健康对照犬。入院90分钟内采集全血样本。采用商业免疫分析法测定血清犬胰脂肪酶免疫反应性浓度，并评估其与椎间盘突出症、体征、神经定位以及入院前糖皮质激素或非甾体抗炎药给药情况的相关性。
椎间盘突出症犬的血清犬胰脂肪酶免疫反应性浓度在统计学上显著升高（P<0.01，n=38）。对犬胰脂肪酶免疫反应性浓度升高的一组犬（19/38）在2至4周后进行重新评估，其中15只犬的临床症状消失，且数值低于200μg/L。血清犬胰脂肪酶免疫反应性浓度与临床胃肠道疾病、神经定位或入院前糖皮质激素或非甾体抗炎药的给药情况无显著相关性。
这些结果表明，椎间盘突出症犬的血清犬胰脂肪酶免疫反应性浓度显著升高。
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