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ACVIM 共识声明:犬胸腰椎间盘突急性症的诊断与管理

ACVIM consensus statement on diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion.

机构信息

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.

出版信息

J Vet Intern Med. 2022 Sep;36(5):1570-1596. doi: 10.1111/jvim.16480. Epub 2022 Jul 25.

Abstract

BACKGROUND

Thoracolumbar intervertebral disc extrusion (TL-IVDE) is the most common cause of acute paraparesis and paraplegia in dogs; however, guidelines on management of the condition are lacking.

OBJECTIVES

To summarize the current literature as it relates to diagnosis and management of acute TL-IVDE in dogs, and to formulate clinically relevant evidence-based recommendations.

ANIMALS

None.

METHODS

A panel of 8 experts was convened to assess and summarize evidence from the peer-reviewed literature in order to develop consensus clinical recommendations. Level of evidence available to support each recommendation was assessed and reported.

RESULTS

The majority of available literature described observational studies. Most recommendations made by the panel were supported by a low or moderate level of evidence, and several areas of high need for further study were identified. These include better understanding of the ideal timing for surgical decompression, expected surgical vs medical outcomes for more mildly affected dogs, impact of durotomy on locomotor outcome and development of progressive myelomalacia, and refining of postoperative care, and genetic and preventative care studies.

CONCLUSIONS AND CLINICAL IMPORTANCE

Future efforts should build on current recommendations by conducting prospective studies and randomized controlled trials, where possible, to address identified gaps in knowledge and to develop cost effectiveness and number needed to treat studies supporting various aspects of diagnosis and treatment of TL-IVDE.

摘要

背景

胸腰椎间盘突出症(TL-IVDE)是犬急性截瘫和四肢瘫痪最常见的原因;然而,目前缺乏关于该病管理的指南。

目的

总结目前与犬急性 TL-IVDE 的诊断和治疗相关的文献,并制定临床相关的循证推荐意见。

动物

无。

方法

召集了一个由 8 名专家组成的小组,评估和总结同行评议文献中的证据,以制定共识临床推荐意见。报告了每个推荐意见所依据的证据的级别。

结果

大多数可用的文献描述了观察性研究。专家组提出的大多数建议都得到了低或中等水平证据的支持,并且确定了几个需要进一步研究的领域。这些领域包括更好地了解手术减压的理想时机、更轻度受影响的犬的预期手术与药物治疗结果、硬脊膜切开术对运动功能预后和进行性脊髓软化的影响,以及完善术后护理、遗传和预防保健研究。

结论和临床意义

未来的研究应在现有建议的基础上进行,开展前瞻性研究和随机对照试验,尽可能地解决知识空白,并制定成本效益和需要治疗的研究,以支持 TL-IVDE 的诊断和治疗的各个方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06bf/9511077/f22c7261e30b/JVIM-36-1570-g001.jpg

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